肠道微生物与卵巢癌关系的研究进展

Advancement in relationship between intestinal microflora and ovarian cancer

卵巢癌是女性生殖器常见的恶性肿瘤之一,因其早期症状不典型,发现时多已发生子宫、对侧附件、大网膜、肠管和盆腔器官转移,且恶化迅速,极易复发,故治疗效果和预后都很差。近年来研究发现,一直以来被认为是无菌的女性上生殖道其实是含有细菌的,而且在卵巢癌女性上生殖道中发现了致病性较强的细菌种类。一个正常成人体内,肠道内微生物的总质量可达1~1. 5 kg,包含的数量可达1 014个,它们相互协调共同导致盆腔各器官慢性炎症的发生,并影响全身各系统疾病的进展。本文就肠道微生物对卵巢癌的发生、发展和治疗的影响进行讨论,总结及初步探讨肠道微生物与卵巢癌的关系及调节肠道微生物稳态在卵巢癌预防和治疗中的应用。

Ovarian cancer is a common malignant tumor of female genital mutilation,because of its early symptoms is not typical,and it was found until the uterus,the contralateral accessoried,greater omentum,bowel and pelvic organ metastasis,and deterioration is rapid,easy to relapse,so the treatment effect and prognosis is poor.In recent years,studies have found that the upper reproductive tract of women who have long been considered sterile actually contains bacteria,and that more pathogenic bacteria have been found in the upper reproductive tract of women with ovarian cancer.A normal adults,in the gut microbial total quality can reach 1~1.5 kg,contain up to 1 014,the number of them coordinate with each other together lead to chronic inflammation,pelvic organs and affect the whole body each system disease progression.In this paper,the gut microbes in ovarian cancer occurrence,development and treatment are discussed,the influence of summarizes and discusses the relationship between gut microbes and ovarian cancer and further adjust the gut microbes steady state in the application of the prevention and treatment of ovarian cancer.