血清硫脑苷脂在心血管疾病和肾功能不全发生发展中的作用

Role of sulfatide in development of cardiovascular diseases and renal dysfunction

硫脑苷脂广泛存在于神经系统、肾脏、肝脏、脾脏、胃、小肠和血清中,血清硫脑苷脂在动脉粥样硬化发病和影响血小板凝血中发挥重要作用。心血管疾病是肾功能不全患者最主要的死亡原因,慢性肾功能不全患者的血清硫脑苷脂水平随肾小球滤过功能下降而逐渐降低。早期根据血清硫脑苷脂水平,对心血管疾病及肾功能不全高风险患者及时采取有效干预措施,或可延缓心、肾功能不全的发生和进展。为此,此文综述血清硫脑苷脂在心血管疾病和肾功能不全发生、发展中的研究进展。

Sulfatide is expressed extensively in the nervous system,kidney,liver,spleen,stomach,small intestine and serum.Sulfatide is reported to play an important role in atherosclerosis,blood clotting and platelet function.Cardiovascular diseasesare the leading cause of death in patients with renal failure.The levels of sulfatide in patients with chronic kidney diseases gradually decreases alongside with glomerular filtration rate deterioration.Early monitoring of serum sulfatide in patients with cardiovascular disease and renal insufficiency promotes early interventions,which help delay the proceeding of heart and renal insufficiency.This article reviews the action of sulfatide on the occurrence and development of cardiovascular diseases and renal failure,and discusses the potential mechanisms.