摘要
目的通过系统综述和网络meta分析比较原发性肝癌7种非手术治疗方法的疗效和安全性。方法通过Pub Med、考克兰图书馆、中国生物医学文献数据库和中国知网数据库检索并筛选,纳入符合要求的临床随机对照试验的原始文献。采用Stata 13.0软件拟合随机效应模型的多变量meta回归,对7种原发性肝癌治疗方法的有效性和安全性进行网络meta分析。结果在7种治疗方法中,肝动脉化疗栓塞与射频消融联合治疗的3年生存率较佳,射频消融的人均不良反应与并发症发生数较低。结论网络meta分析有助于同时比较原发性肝癌多种热消融治疗方法的有效性和安全性。原发性肝癌热消融应首选肝动脉化疗栓塞与射频消融的联合治疗。
Objective To compare the efficacy and safety of seven non-surgical therapies for primary hepatic carcinoma(PHC)based on a network meta-analysis.Methods References related to eligible randomized controlled trials(RCTs)were searched from PubMed,The Cochrane Library,China Biology Medicine disc and China National Knowledge Infrastructure and selected according to criteria.Multivariate meta-analysis was performed to assess the efficacy and safety of seven types of therapies for PHC by fitting random effects model with Stata 13.0.Results Among seven types of therapies,the combination of transcatheter arterial chemoembolization(TACE)and radiofrequency ablation(RFA)had a better three-year survival rate,and RFA alone had less adverse events and complications.Conclusion Network metaanalysis contributes to the simultaneous comparison of efficacy and safety of several thermal ablation therapies for PHC.The combination therapy of TACE and RFA is suggested to be the first choice.
作者
熊琨
陈丹妮
白飞
魏雪峰
薛迪
XIONG Kun;CHEN Dan-ni;BAI Fei;WEI Xue-feng;XUE Di(School of Public Health,Fudan University,Key Lab of Health Technology Assessment,National Health and Family Planning Commission,Shanghai 200032,China;;Center for Medical Service Administration,National Health Commission,Beijing 100044,China;Health and Family Planning Commission of Gansu,Lanzhou 730030,Gansu China)
出处
《中国卫生资源》
北大核心
2018年第4期307-311,322,共6页
Chinese Health Resources
关键词
原发性肝癌
热消融
射频消融
微波消融
激光消融
高强度聚焦超声
肝动脉化疗栓塞
有效性
安全性
网络meta分析
primary hepatic carcinoma
thermal ablation
radiofrequency ablation
microwave ablation
laser ablation
high intensity focused ultrasound
transcatheter arterial chemoembolization
efficacy
safety
network metaanalysis
