体重管理干预对肥胖型PCOS患者糖脂代谢的影响

Effect of weight management intervention on glucose and lipid metabolisms in obese patients with polycystic ovary syndrome

目的探讨体重管理干预对肥胖型多囊卵巢综合征(PCOS)患者糖脂代谢的影响。方法选取肥胖型PCOS患者70例,按照患者是否愿意接受体重管理,将其分为干预组和对照组,分别测定并分析两组患者0、15、30及45 d干预糖脂代谢指标。结果 (1)干预后不同时间点的TG、TC、FPG、2 h PPG、FINS及PINS比较有差异(P<0.05);(2)两组患者干预后的TG、TC、2 h PPG、FINS及PINS比较有差异(P<0.05);(3)两组患者的TG、TC、2 h PPG及PINS变化趋势比较有差异(P<0.05)。结论肥胖型PCOS患者在药物治疗的基础上实施体重管理,能更有效地改善患者糖脂代谢异常,增强药物疗效。

Objective To explore the effect of weight management on the glucose and lipid metabolisms in the obese patients with polycystic ovary syndrome(PCOS).Methods A total of 70 obese women with PCOS were divided into two groups with the control group administered by Metformin and the intervention group managed with weight management in addition to Metformin.The glucose and lipid metabolism indicators were measured and compared on day 0,15,30 and 45.Results The levels of TG,TC,FPG,2hPPG,FINS and PINS after intervention had significant differences at different time points(P<0.05).The levels of TG,TC,2hPPG,FINS and PINS after intervention had significant differences between the 2 groups(P<0.05).The variation trends of TG,TC,2hPPG and PINS had significant differences between the 2 groups(P<0.05).Conclusions The weight management on the basis of drug therapy for the obese patients with PCOS can significantly improve the metabolic disorders and enhance the effect of drug therapy.