羟乙基淀粉联合前列地尔对老年急性脑分水岭梗死患者的康复疗效及认知预后的影响

Effect of hydroxyethyl starch combined with Alprostadil on rehabilitation and cognitive outcomes of elderly patients with acute cerebral watershed infarction

目的研究羟乙基淀粉联合前列地尔对老年急性脑分水岭梗死患者的康复疗效及认知预后的影响。方法选取从2014年2月-2016年4月于南阳市中心医院接受治疗的急性脑分水岭梗死患者206例,根据随机数字表法分为观察组与对照组各103例。所有患者入院后均给予常规治疗,观察组则在此基础上加用羟乙基淀粉联合前列地尔治疗,比较两组治疗效果。结果观察组总有效率为95.15%(98/103),高于对照组的84.47%(87/103);治疗后1周和2周的观察组神经功能缺损评分均低于对照组,而Barthel指数均高于对照组,上述差异均有统计学意义(P<0.05)。结论羟乙基淀粉联合前列地尔对老年急性脑分水岭梗死患者的康复疗效显著,能明显改善患者神经功能。

Objective To study the effect of hydroxyethyl starch combined with Alprostadil on rehabilitation and cognitive outcomes of elderly patients with acute cerebral watershed infarction.Methods From February 2014 to April 2016,206 patients with acute cerebral watershed infarction were treated in our hospital.According to random number table method they were divided into an observation group and a control group,each had 103 cases.After admission,all of the patients were given conventional treatment,those in the observation group were added with hydroxyethyl starch combined with Alprostadil treatment.The treatment results were compared between the two groups.Results The total effective rate of the observation group was 95.15%(98/103),which was significantly higher than 84.47%(87/103)of the control group.After treatment for 1 week and 2 weeks,the neural function defect score of the observation group was significantly lower than that of the control group,the Barthel index of the observation group was significantly higher than that of the control group,the differences were statistically significant(P<0.05).Conclusions Hydroxyethyl starch combined with Alprostadil has significantly curative effect for the rehabilitation of elderly patients with acute cerebral watershed infarction,and can significantly improve the neurological function of the patients.