食管鳞癌组织MTA2、CD34的表达及其临床意义

Expressions of MTA2 and CD34 in esophageal squamous cell carcinoma and their clinical significances

目的探讨食管鳞状细胞癌(ESCC)组织侵袭转移与肿瘤转移相关基因2(MTA2)、CD34蛋白表达的关系。方法选择80例食管鳞癌组织作为观察组,30例正常的食管黏膜组织作为对照组,应用免疫组化法检测两组中MTA2及CD34的表达情况,分析MTA2表达水平与临床病理特征的关系及与CD34标记的微血管密度(MVD)表达的相关性。结果 MTA2在食管鳞癌组织中的阳性表达和微血管密度(MVD)呈正相关(r=0.777,P <0.01),MTA2表达与浸润深度、淋巴结是否转移及TNM分期呈正相关,与分化程度呈负相关(r=-0.645,P <0.05)。食管鳞癌组织中MVD与癌组织大小、浸润深度、TNM分期、分化程度及淋巴结是否转移有关(P <0.05)。结论联合检测MTA2和CD34的表达可能为诊断食管鳞状细胞癌转移提供重要依据,并为抗食管鳞癌血管生成治疗提供新的靶点。

Objective To investigate the relationship between the invasion and metastasis of esophageal squamous cell carcinoma(ESCC)and the expressions of tumor metastasis related gene2(MTA2)and CD34.Methods The expressions of MTA2 and CD34 in normal esophageal tissues(30 cases)and ESCC tissues(80 cases)were detected with immuneohistochemical staining.The correlations between MTA2,clinical and pathologi-cal features of ESCC,and microvessel density(MVD)labeled by CD34 were analyzed.Results The expression of MTA2 was positively correlated not only with MVD in ESCC(r=0.777,P<0.01).In addition,the expression of MTA2 was positively correlated with depth of tumor invasion,lymph node metastasis and TNM stage,but nega-tively correlated with the degree of differentiation of ESCC(r=-0.645,P<0.05).MVD was positively correlated significantly with tumor size,depth of invasion,TNM stage,tumor differentiation degree and lymph node metasta-sis in ESCC(P<0.05).Conclusion The combining detection of both MTA2 and CD34 expressions may provide an important basis for diagnosis of ESCC metastasis and new targets for anti-angiogenic therapy for ESCC.