微流控纺丝制备葡萄糖响应凝胶纤维

Fabrication of Glucose-Responsive Gel Fibers via Microfluidic Spinning

葡萄糖响应凝胶纤维在血糖监测传感器开发中有着潜在的应用前景。本文基于微流控纺丝方法和自由基聚合反应制备了化学交联和物理交联的葡萄糖响应聚(N-异丙基丙烯酰胺/3-丙烯酰胺基苯硼酸)(P(NIPAM-co-AAPBA))凝胶纤维。通过傅里叶变换红外光谱、扫描电子显微镜和力学性能测试等技术手段表征了凝胶纤维的结构和形态、力学性能、溶胀度动力学与葡萄糖响应性。结果表明,凝胶纤维具有多孔的微观结构,通过改变芯层与壳层溶液的流速可以调控凝胶纤维的直径。随着AAPBA质量分数的增加,凝胶纤维的溶胀速率和平衡溶胀度均有所降低,但葡萄糖响应性能提高。与化学交联的凝胶纤维相比,物理交联的凝胶纤维具有良好的力学性能。

Glucose responsive gel fibers have potential application prospects in the development of glucose sensors for monitoring blood glucose levels.In this work,poly(N-ispropylacrylamide/3-acrylamidophenylboronic acid)(P(NIPAM-co-AAPBA))glucose sensitive hydrogel fibers were fabricated via microfluidic spinning and off-chip free radical polymerization reaction.The structure and morphology,mechanical properties,swelling kinetics and glucose responsiveness of the gel fibers were characterized by Fourier transform infrared spectrometer(FTIR),scanning electron microscopy(SEM)and mechanical test.The results show that the gel fibers have porous microstructures,and their diameters could be controlled by changing the flow rates of the core and sheath layer solution.With the increase of AAPBA mass fraction,the swelling rate and equilibrium swelling degree of the gel fibers are decreased,but the glucose response performance is improved.Compared with the chemically cross-linked gel fibers,the physically cross-linked gel fibers have good mechanical properties.