树枝状介孔二氧化硅的制备及其负载纳米银的抗菌性

Preparation of Dendritic Mesoporous Silica and Its Antibacterial Properties of Loaded Nano Ag

以正硅酸乙酯为硅源(TEOS),十六烷基三甲基溴化铵(CTAB)为表面活性剂,采用溶胶-凝胶法在氨水催化下制备树枝状介孔二氧化硅微球。以该微球为载体,原位负载纳米银。探究乙醚、硅烷结构助剂加入量对介孔二氧化硅微球的形貌、结构和粒径的影响,并通过抗菌实验测试其样品的最低抑菌浓度(MIC)和最小杀菌浓度(MBC)。结果表明:硅烷结构助剂和乙醚的加入对树枝状孔道的生成是至关重要的;纳米银负载到该介孔二氧化硅的MIC在3.16~3.95mg·L-1,MBC为6.32mg·L-1,优于纯纳米银。

Dendritic mesoporous silica microspheres were prepared by sol-gel method with ammonium as catalyst,TEOS as silica source and CTAB as surfactant.Nano Ag was in-situ loaded in the SiO 2 microspheres.The effect of different amounts of ether and silane structure promoter on the morphology,structure and particle size of dendritic mesoporous SiO 2 microspheres was studied.The minimum inhibitory concentration(MIC)and minimum bactericidal concentration(MBC)of the samples were tested by antibacterial examination.The results show that the addition of silane structure promoter and ether is crucial to the formation of dendritic pores.The MIC of nano Ag in the mesoporous silica is between 3.16mg·L^-1 and 3.95mg·L^-1,the MBC is 6.32mg·L^-1.Both of them are superior to pure nano Ag in antibacterial properties.