孟鲁司特钠联合硫酸沙丁胺醇治疗小儿咳嗽变异性哮喘的临床效果及安全性

Clinical efficacy and safety of Montelukast combined with salbutamol sulfate in the treatment of children with cough variant asthma

目的:探讨孟鲁司特钠联合硫酸沙丁胺醇治疗小儿咳嗽变异性哮喘的效果及安全性。方法:收治咳嗽变异性哮喘患儿300例,将其分为对照组和观察组,各150例。对照组采用硫酸沙丁胺醇治疗,观察组在此基础上加用孟鲁司特钠治疗。结果:观察组治疗后临床总有效率明显高于对照组(P<0.05);两组治疗后FVC、FEV1、FEV1.0%、PEF水平与治疗前比较差异显著,且观察组改善更明显(P<0.05)。结论:孟鲁司特钠联合硫酸沙丁胺醇治疗小儿咳嗽变异性哮喘可缓解咳嗽症状,有效改善肺功能,防止哮喘恶化,且安全可靠,在临床上治疗哮喘可优先考虑此联合方案。

Objective:To explore the efficacy and safety of Montelukast combined with salbutamol sulfate in the treatment of children with cough variant asthma.Methods:300 children with cough variant asthma were selected.They were divided into the control group and the observation group with 150 cases in each.The control group were treated with salbutamol sulfate,and the observation group were treated with montelukast sodium based on the treatmen given in the control group.Results:The clinical total effective rate of the observation group was significantly higher than that of the control group(P<0.05).The levels of FVC,FEV1,FEV1.0%and PEF in the two groups were significantly different from those before the treatment,and the improvement of the observation group was more obvious(P<0.05).Conclusion:Montelukast combined with salbutamol sulfate can relieve cough symptoms in children with cough variant asthma,improve lung function effectively,prevent asthma from worsening,and be safe and reliable.This combined regimen can be considered in clinical treatment of asthma.