慢性肾衰竭血透患者阿司匹林抵抗状况研究

Aspirin resistance in hemodialysis patients with chronic renal failure

目的:探讨慢性肾衰竭行血透(MHD)患者发生以及影响阿司匹林抵抗情况的因素。方法:收治慢性肾衰竭患者100例,凝血功能经检查呈现正常与高凝状态50例患者为试验组,肾功能正常与肾小球滤过率>90 m L/(min×1.73/m2)50例患者为对照组。结果:试验组中患者超敏C反应蛋白(hs-CRP)、同型半胱氨酸(Hcy)、R各值明显超过对照组,MA值小于对照组(P<0.05)。抵抗组患者与敏感组患者的FBG、hs-CRP、Hcy、R、MA对比差异有统计学意义(P<0.05),糖尿病、年龄、透析时间、hs-CRP、Hcy是慢性肾衰竭行MHD患者引发AR的独立危险因素(P<0.05)。结论:糖尿病、年龄、透析时间、hs-CRP、Hcy是慢性肾衰竭行MHD患者引发AR的独立危险因素。

Objective:To investigate the occurrence of hemodialysis patients and factors affecting aspirin resistance in patients with chronic renal failure.Methods:100 patients with chronic renal failure were treated,and 50 patients with normal and hypercoagulable state were examined as the experimental group,and 50 patients with normal renal function and glomerular filtration rate higher than 90 mL/(min×1.73/m2)were treated as the control group.Results:The values of hypersensitive C reactive protein(hs-CRP),homocysteine(Hcy)and R in the experimental group were significantly higher than those in the control group,and the MA value was less than that of the control group(P<0.05).The differences in FBG,hs-CRP,Hcy,R and MA were statistically significant(P<0.05)in the patients with the resistance group and the sensitive group(P<0.05).CY is an independent risk factor for AR in patients with chronic renal failure(MHD<0.05).Conclusion:Diabetes,age,dialysis time,hs-CRP and Hcy are independent risk factors for AR in MHD patients with chronic renal failure.