牙龈卟啉单胞菌与食管癌临床病理特征和预后的关系

The relationship between Porphyromonas gingivalis and clinicopathological characteristics and prognosis of esophageal cancer

目的检测牙龈卟啉单胞菌(PG)在食管黏膜中的表达,以及PG与食管鳞癌(ESCC)诊断及预后的关系。方法通过免疫组织化学SP法检测PG及其分泌的独特蛋白酶Kgp在ESCC组织、癌旁组织及正常食管黏膜中的表达。并分析PG感染和ESCC临床特征的关系。结果 PG在ESCC组织、癌旁组织、正常食管黏膜的阳性表达率分别为60%、15%、0;Kgp的阳性表达率分别为68%、40%、0,PG感染与分化程度、淋巴结转移及TNM分期正相关。结论 PG感染ESCC患者的食管上皮细胞,且与ESCC进展有关,它可能是ESCC的生物标志物;根治口腔病原菌可能减少ESCC的发生。

Objective To detect the expression of Porphyromonas gingivalis(PG)in the esophageal mucosa and the relationship between PG and the diagnosis and prognosis of esophageal squamous cell carcinoma(ESCC).Methods The immunohistochemical SP method was used to detect the expression of PG and its Unique protease Kgp in percutaneous tissue,adjacent normal tissues and normal esophageal mucosa.The relationship of PG infection and clinicopathologic characteristics of ESCC was analyzed.Results The positive expression rate of PG in percutaneous tissue,adjacent normal tissues and normal esophageal mucosa was 60%,15%,0,and the positive expression rate of Kgp was 68%,40%,0 respectively.PG infection was positively correlated with differentiation,lymph node metastasis and TNM stage.Conclusion PG infects the epithelium of the esophagus of ESCC patients,PG infection is associated with the progression of ESCC,it may be a biomarker of ESCC.Eradication of PG may reduce the incidence of ESCC.