康复技能训练对抑郁症患者症状缓解和生活质量的作用

Effects of the structured rehabilitation skills training program in the improvement of depressive symptoms and quality of life in patients with major depressive disorder

目的探讨抑郁症康复技能训练对抑郁症患者症状缓解及生活质量的效果。方法把212例符合入组标准的抑郁症患者,采用分层随机分组的方法分为技能训练组(102例)和健康教育组(110例)。技能训练组接受抑郁症康复技能训练程式干预,健康教育组接受抑郁症相关知识讲座,对两组患者均随访观察1年。每3个月对两组患者进行随访评估,评估工具包括:一般情况调查表、17项汉密尔顿抑郁量表(Hamilton Depression Rating Scale for Depression-17 item,HAMD-17)、世界卫生组织生存质量测定量表简表(World Health Organization's Quality of Life Instruments-Abbreviated Version,WHOQOL-BREF)。采用SPSS 17.0统计软件进行数据分析。结果 (1)HAMD-17总分组间和组内差异均有统计学意义,技能训练组随访时点3、6、9、12个月均显著低于健康教育组(均P <0.05)。(2)WHOQOL-BREF自评总分及生存质量自评、健康状况满意度自评组间和组内差异均有统计学意义,技能训练组随访时点6、9、12个月各因子分均高于健康教育组(均P <0.05)。结论抑郁症康复技能训练程式能有效缓解抑郁症患者症状,促进患者生活质量提高。

Objective To examine the effects of the structured rehabilitation skills training program on the improvement of depressive symptoms and quality of life in patients with major depressive disorder(MDD).Methods A total of 212 patients with MDD who met the inclusion criteria of this study were divided into two groups,namely intervention group(conventional treatment combined with the whole rehabilitation skills training program,n=102)and control group(conventional treatment combined with general health education,n=110).Depressive symptoms and quality of life were assessed using HAMD-17(Hamilton Depression Rating Scale for Depression-17 item),WHOQOL-BREF(World Health Organization s Quality of Life Instruments-Abbreviated Version)at baseline and at every follow-up visit in 1 year(every 3 months).All outcomes were analyzed using SPSS 17.0 software.Results The difference between groups and intra-group differences of HAMD-17 total score and each factor score and total score of WHOQOL-BREF were statistically significant.HAMD-17 total score in intervention group are significantly lower than that in control group at 3nd,6th,9th and 12th month.Total score and each factor score of WHOQOL-BREF in intervention are significantly higher than that in control group at 6th,9th and 12th month.Conclusion Skills training program for patients with major depressive disorder established in this study is mostly reasonable,and it is effective in improving depressive symptoms and life quality.