血清类黏蛋白的功能和临床意义

Function and clinical role of serum orosomucoid

类黏蛋白(ORM)属于急性时相反应蛋白,机体许多组织和细胞均能合成,但主要的合成器官是肝脏。ORM能够调节参与天然免疫和获得性免疫的多种细胞,平衡机体的能量代谢,并具有抗疲劳作用。许多组织损伤均可诱导细胞及血中的ORM升高。在感染和创伤的过程中,血中ORM水平在炎症的多个阶段均持续升高。因此,监测血中ORM水平能够与C反应蛋白(CRP)互补,反映炎症性疾病的持续、进展和消退情况,从而为精准治疗提供新的线索。文章从ORM的结构特征、生物功能以及检测ORM的临床意义等方面对ORM进行综合性的阐述。

Orosomucoid(ORM)is an acute phase reactive protein synthesized by many tissues and cells,but the liver is the main organ that synthesizes ORM.ORM can adjust various cells participating in innate and acquired immunity,balance energy metabolism,and fight fatigue.The levels of ORM in cells and blood have been shown to increase dramatically resulting from various tissue injuries.In the process of infection or trauma,blood ORM levels are continuously elevated in the multiple phases of inflammation.Therefore,monitoring the level of ORM in blood can be complemented with the current clinical index of emergency response C-reactive protein(CRP).ORM can reflect the persistent,progress and fade status of inflammatory diseases and provide new clues to precise treatment.This review makes a comprehensive exposition of ORM from the aspects of structure,biological function and clinical significance of determining ORM.