^(18)F-FDG PET/CT评价胃肠间质瘤恶变潜能:Meta分析

^(18)F-FDG PET/CT in evaluation on malignant potential of gastrointestinal stromal tumors:Meta-analysis

目的采用Meta分析评价18 F-FDG PET/CT评价胃肠间质瘤(GIST)恶变潜能的价值。方法检索PubMed、EMBASE、Cochrane图书馆、中国知网和中国生物医学数据库中有关18 F-FDG PET/CT评价GIST恶变的中英文文献,检索时间截止2017年12月。由2名研究者进行数据提取和质量评价后,采用Meta-Disc软件进行统计分析。结果共纳入6项研究、157例患者。Meta分析结果显示,合并敏感度、合并特异度、合并阳性似然比、合并阴性似然比及合并诊断比值比分别为0.85[95%CI(0.76,0.92)]、0.79[95%CI(0.68,0.87)]、3.35[95%CI(1.81,6.20)]、0.22[95%CI(0.13,0.37)]及18.28[95%CI(6.31,52.95)],汇总ROC(SROC)曲线下面积为0.9057(P<0.05)。Deek's漏斗图提示存在发表偏倚的可能性较小。亚组分析和Meta回归分析结果显示诊断试验的准确率基本不受设备型号和SUVmax临界值的影响。结论 18F-FDG PET-CT评价胃肠间质瘤恶变潜能具有较高诊断效能。

Objective To explore the value of 18 F-FDG PET/CT in evaluation on the malignant potential of gastrointestinal stromal tumors(GIST)with Meta-analysis.Methods The database of PubMed,EMBASE,Cochrane Library,CNKI and CBM were researched from establishment to December 2017,for the diagnostic studies about assessing the malignant potential of GIST using 18 F-FDG PET/CT.The data were extracted,and the quality of included studies was assessed by 2 reviewers,and then were analyzed with Meta-Disc software.Results Totally 6 studies involving 157 patients were included.Meta-analysis showed that the pooled sensitivity,pooled specificity,pooled positive likelihood ratio,pooled negative likelihood ratio and diagnostic odds ratio was 0.85(95%CI[0.76,0.92]),0.79(95%CI[0.68,0.87]),3.35(95%CI[1.81,6.20],0.22(95%CI[0.13,0.37])and 18.28(95%CI[6.31,52.95]),respectively,and the AUC of summary ROC(SROC)was 0.905 7(P<0.05).Deek's funnel plot showed that the possibility of publication of bias was small.The subgroup analysis and Meta-regression results indicated that the equipment model and the threshold of SUV max did not obviously influence the accuracy of 18 F-FDG PET/CT.Conclusion There was high diagnostic efficacy for 18 F-FDG PET/CT in assessing the malignant potential of GIST.