卒中后抑郁的研究进展

Research progress on something about post-stroke depression(PSD)

卒中后抑郁是指脑卒中患者在卒中后发生的一种包含多种精神和躯体症状的情感障碍,发生率约为20%～50%,主要表现为情绪低落、兴趣减退、烦躁悲观、全身疲倦等症状,可严重影响患者的生活质量。卒中后抑郁的发病机制可能与脑血管病变造成调节情感的神经通路、神经递质、神经营养因子等异常有关,其治疗方式主要有药物治疗和非药物治疗。药物治疗主要使用抗抑郁药,如单氨氧化酶抑制剂(MAOIs)、三环类药物(TCAs)、5-HT再摄取抑制剂(SSRIs)等。非药物治疗主要包括物理、心理、高压氧以及运动治疗等。多种方法可结合应用,为卒中后抑郁患者提供更完善的治疗方案。

Post-stroke depression(PSD)means the emotion dysfunction of stroke patients,including psychological and body symptoms after stroke,that's incidence is between 20%and 50%.Its main clinical symptoms are the low mood,insterets reduction,pessimism and fatigue in whole body,etc,which could severely influence patients’quality of life.PSD’s mechanism relates probably to nerve pathway,neurotransmitter and neurotrophic factor which modulate human emotion.Its therapies mainly include drug therapy and non-drug therapy.Drug therapy means to use antidepressant such as MAOIs,TCAs,SSRIs,etc.Non-drug treatments include physical,psycological,hyperbaric oxygenation and exercise therapy,etc.All kinds of the therapies might provide better therapeutic scheme for PSD patients.