超声辅助提取/单颗粒电感耦合等离子体质谱法测定防晒化妆品中的纳米二氧化钛

Determination of Nano-TiO_2 in Sunscreen by Single Particle Inductively Coupled Plasma-Mass Spectrometry with Ultrasound-assisted Extraction

建立了超声辅助提取/单颗粒电感耦合等离子体质谱(SP-ICP-MS)测定防晒化妆品中纳米TiO_2的方法。考察了停留时间、纳米粒子数量及浓度等分析条件,确定了防晒化妆品中纳米TiO_2的最佳萃取条件以及测定方法,对比了不同萃取溶剂对防晒霜中纳米TiO_2的提取效果。结果表明,在采用0. 1%Tritonx-100(Tx-100)以及5%乙醇作为萃取剂超声辅助提取,测定停留时间为3 ms,待测样品中纳米颗粒的数量浓度低于4×10~7个/mL条件下,该法可准确测定防晒化妆品中的纳米TiO_2,对防晒化妆品中纳米TiO_2的数量浓度检出限(LOD_(conc))为1×10~4个/mL,纳米颗粒粒度检出限(LOD_(size))为35 nm。方法简单快捷、灵敏度高、准确性良好,可同时对防晒化妆品中TiO_2进行浓度测定及粒度分布表征。

A novel method combining ultrasound assisted extraction with single particle inductively coupled plasma-mass spectrometry(SP-ICP-MS)was developed for the analysis of nano-TiO 2 in sunscreen.To obtain the optimal extraction and analysis conditions,the experimental factors such as extraction solvents,dwell time and number concentration of nano-TiO 2 were investigated.Result showed that the optimum dwell time was 3 ms and the upper concentration limit for nano-TiO 2 was 4×10 7 particles/mL.The nano-TiO 2 in sunscreen could be extracted effectively by ultrasound-assisted extraction with 0.1%Tritonx-100 and 5%ethanol as extracting agents.The method could be used for the detection on nano-TiO 2 in sunscreen with a detection limit for number concentration(LOD conc)of 1×10 4 particles/mL and a detection limit for particle size(LOD size)of 35 nm.With the advantages of simplicity,rapidness,good sensitivity and accuracy,the method could be applied in the simultaneous determination and characterization on concentration and particle size distribution of nano-TiO 2 in sunscreen.