正常脑老化中静息态功能磁共振成像功能连接的研究进展

Advances in research of resting-state fMRI functional connectivity in normal brain aging

静息态功能磁共振成像(fMRI)作为一种不需要任务刺激就能呈现功能脑影像的技术手段,在临床上被广泛应用。基于静息态fMRI的静息态功能连接(RSFC),作为一种重要的计算机辅助分析法,能够度量不同脑区的脑功能连接强度,对脑老化相关的神经科学领域的研究具有重要意义。本文介绍了功能连接的基本概念,总结了近年来脑老化相关的人脑功能连接的研究成果,最后提出了该研究领域存在的问题及未来的研究方向。

As a task-free modality of functional magnetic resonance imaging(fMRI)data acquisition and image display,resting-state fMRI is widely used in clinical application.The resting-state functional connectivity based on resting-state fMRI,an important computer-aided analysis method,can be used to detect the fluctuations in brain activity across separate brain regions,which is of great significance for the research of neuroscience related to brain aging.Herein,some basic concepts of functional connectivity were firstly introduced.Then the recent progresses in human brain functional connectivity related to brain aging were summarized.Finally,the existing problems and the development trends of the research of resting state fMRI functional connectivity in normal brain aging were put forward.