阿加曲班联合阿替普酶静脉溶栓治疗急性脑梗死的疗效及脑血管储备功能的影响

Effect of Argatroban Combined with Alteplase Intravenous Thrombolysis on Acute Cerebral Infarction and Cerebrovascular Reserve Function

目的:探讨阿加曲班联合阿替普酶静脉溶栓治疗急性脑梗死的疗效及脑血管储备功能的影响。方法:回顾性分析2016年7月至2017年12月我院收治的急性脑梗死患者122例,以对照组和研究组两种模式进行分组,对照组进行阿替普酶静脉溶栓治疗,研究组在此基础上加以进行阿加曲班治疗,对比两组临床疗效、神经功能评分、血清BNP、CRP水平以及脑血管储备功能。结果:研究组急性脑梗死患者进行阿加曲班联合阿替普酶静脉溶栓治疗后的总有效率显著比对照组高(P<0.05);治疗前两组患者的GCS评分、ADL评分都无明显差别(P>0.05),治疗后研究组急性脑梗死患者的GCS评分、ADL评分均明显比对照组高(P<0.05);治疗前两组急性脑梗死患者的血清BNP、CRP水平无明显差别(P>0.05),治疗后研究组急性脑梗死患者的血清BNP、CRP水平明显比对照组低(P<0.05);治疗前两组急性脑梗死患者的脑血管储备功能无明显差距(P>0.05),治疗后研究组急性脑梗死患者的脑血管储备功能明显优于对照组(P<0.05)。结论:阿加曲班联合阿替普酶静脉溶栓治疗急性脑梗死的疗效显著,可有效加强患者的神经功能以及脑血管储备功能,改善血清BNP、CRP水平,安全可靠,值得临床推广。

Objective:To investigate the effect of argatroban combined with alteplase intravenous thrombolysis in the treatment of acute cerebral infarction and the influence of cerebrovascular reserve function.Results:122 patients with acute cerebral infarction admitted to our hospital from July 2016 to December 2017 were analyzed retrospectively.All the patients were divided into control group and study group,The patients in control group were treated with alteplase intravenous thrombolytic therapy,and the patients in study group were treated with argatroban.the clinical efficacy.The neurological function score,serum BNP,CRP level and cerebrovascular reserve function were compared between the two groups.Results:The total efficiency of Agha Argatroban combined with intravenous thrombolytic therapy in acute cerebral infarction in the study group was significantly higher than that in the control group(P<0.05).The clinical efficacy of argatroban combined with alteplase intravenous thrombolysis in the study group was significantly better than that in the control group(P<0.05).There was no significant difference in GCS score and ADL score between the two groups before treatment(P>0.05).After treatment,GCS score and ADL score of patients with acute cerebral infarction in the study group were significantly higher than those in the control group(P<0.05).There was no significant difference in serum BNP and CRP levels between the two groups before treatment(P>0.05).after treatment,the serum BNP and CRP levels in the study group were significantly lower than those in the control group(P<0.05).There was no significant difference in cerebrovascular reserve function between the two groups before treatment(P>0.05),and the cerebrovascular reserve function of the study group was significantly better than that of the control group after treatment(P<0.05).Conclusion:Argatroban combined with alteplase intravenous thrombolysis in the treatment of acute cerebral infarction curative effect is remarkable.It can effectively strengthen the patient's nerve function and cerebrovascular reserve function,and improve the serum BNP,CRP levels,safe and reliable,It's worthy of clinical promotion.