通脑饮治疗急性脑梗死的临床疗效及对患者血液流变学影响

Effect of Tongnao Decoction in Treating Acute Cerebral Infarction and Its Effect on Hemorrheology

目的:探讨通脑饮治疗急性脑梗死(ACI)的临床疗效及对该疾病患者血液流变学的影响。方法:采用随机抽签法将确诊后入组的100例患者均分为两组,对照组选择西药进行常规对症处理,观察组则此基础上服用通脑饮。测定两组治疗前后血流动力学指标ηb、HCT、Fib、PAG、MST,血清D-D、VEGF含量变化;比较两组治疗前及治疗后3个月时脑血流动力学指标MPV、DBFV、MBF、VPI、RI变化情况;对比NHISS评分;两组统计两组临床疗效。结果:观察组痊愈率(54.00%)、总有效率(94.00%)均明显高于对照组(30.00%和78.00%),两组间差异均具有统计学意义(P<0.05)。两因素重复测量资料方差分析显示:两组治疗前后血液流变性指标ηb、HCT、Fib、PAG、MST和脑血流动力学指标MPV、DBFV、MBF、VPI、RI间差异存在统计学意义(P<0.05);对照组与观察组ηb、HCT、Fib、PAG、MST、MPV、DBFV、MBF、VPI及RI间差异存在统计学意义(P<0.05)。结论:通脑饮治疗ACI,可有效降低血液黏度,改善血流动力学,加速脑组织血液循环,促进患者神经功能修复,疗效确切。

Objective:To investigate the clinical efficacy of Tongnao Decoction in the treatment of acute cerebral infarction(ACI)and its effect on blood circulation in patients with this disease.Methods:The randomized method was used to divide the 100 patients admitted into the group into two groups.The control group selected western medicine for routine symptomatic treatment,and the observation group took Tongnao Decoction on the basis of western medicine for routine symptomatic treatment.The changes of hemodynamicsηb,HCT,Fib,PAG,MST,serum D-D and VEGF were measured before and after treatment.The change of cerebral hemodynamic parameters MPV,DBFV,MBF,VPI and RI before and 3 months after treatment were compared between the two groups.The NHISS scores were compared between the two groups.The clinical efficacy of the two groups was statistically analyzed.Results:The cure rate(54.00%)and total effective rate(94.00%)in the observation group were significantly higher than those in the control group(30.00%and 78.00%respectively).The difference between the two groups was statistically significant(P<0.05).Analysis of variance of two-factor repeated measures showed that there were statistically significant differences inηb,HCT,Fib,PAG,MST,MPV,DBFV,MBF,VPI and RI before and after treatment(P<0.05);There was significant difference between the control group and the observation group inηb,HCT,Fib,PAG,MST,MPV,DBFV,MBF,VPI and RI(P<0.05).Conclusion:Tongnaoyin treatment of ACI,can effectively reduce blood viscosity,improve hemodynamics,accelerate blood circulation of brain tissue,promote the repair of nerve function in patients,the curative effect is definite.