长春地辛与长春新碱在儿童急性淋巴细胞性白血病应用中不良反应的对比

Comparison of Adverse Reactions between Vindesine and Vincristine in Children with Acute Lymphoblastic Leukemia

目的:探讨长春地辛与长春新碱在儿童急性淋巴细胞性白血病应用中不良反应的对比。方法:选择2013年2月至2015年2月我院收治的儿童急性淋巴细胞性白血病患者90例,随机分为观察组45例,对照组45例。观察组采用长春地辛3mg/m2进行治疗。对照组采用长春新碱1.5mg/m2进行治疗。比较两组患者的临床疗效及临床特征和平均住院费用;记录比较两组患者不良反应发生情况。结果:治疗后,两组患者CR率、早期死亡率和缓解时间及治疗相关死亡率差异均无统计学意义(P>0.05);治疗后,两组患者临床特征无显著性差异(P>0.05);两组患者在诱导缓解期和延迟强化期,住院费用包括药品费、检查费、治疗费、护理费、输血费、材料费及床位费。观察组平均住院费为25995元/人,对照组平均住院费用为34245元/人,两组差异具有统计学意义(P=0.001);观察组患者血小板减少、贫血及神经系统毒素发生率低于对照组,差异具有统计学意义(P<0.05)。结论:长春地辛和长春新碱治疗儿童急性淋巴细胞性白血病早期疗效无明显差异,但使用长春地辛治疗儿童急性淋巴细胞性白血病不良反应发生率和住院费用均低于使用长春新碱治疗。

Objective:To study comparison of adverse reactions between changchun dixin(VDS)and vincristine(VCR)in the application of acute lymphocytic leukemia in children.Methods:90 patients with acute lymphoblastic leukemia in our hospital were selected from February 2013 to February 2015,there were 45 cases in VDS group and 45 in the VCR group.VDS group was treated with VDS3mg/m2.VCR group was treated with vcr1.5mg/m2.The clinical efficacy and clinical characteristics of the two groups were compared with the average hospitalization expenses.The adverse reactions of the two groups were recorded.Results:After treatment,there was no statistically significant difference between CR rate,early death rate and remission time in both groups(P>0.05).After treatment,there was no significant difference in clinical features between the two groups(P>0.05);In the two groups of patients,the hospitalization expenses include drug charge,examination fee,treatment fee,nursing fee,blood transfusion fee,material fee and bed fee.The average hospitalization expense of the VDS group was 25,995 yuan/person,and the average hospitalization expense of the VCR group was 34245 yuan/person,and the difference between the two groups was statistically significant(P=0.001).The incidence of thrombocytopenia,anemia and neurotoxin in the VDS group was lower than that in the VCR group,and the difference was statistically significant(P<0.05).Conclusion:VDS and VCR early curative effect of treatment of children with acute lymphocytic leukemia has no obvious difference,but the use of VDS for children with acute lymphocytic leukemia incidence of adverse reactions and hospitalization costs are lower than using a VCR.