冠心病患者血小板体积分布宽度、胱抑素C与冠脉病变严重程度的关系

Correlation between platelet distribution width,cystatin C and severity of coronary artery disease in patients with coronary heart disease

目的探讨冠心病患者血小板体积分布宽度(PDW)、胱抑素C(Cystain C)与冠脉病变严重程度的关系。方法回顾性分析2016年8月-2017年10月在新疆医科大学第一附属医院行冠状动脉造影(CAG)并符合纳入条件的896例冠心病患者的临床数据。根据患者病史将冠心病患者分为稳定型心绞痛组(408例)和不稳定型心绞痛组(488例)。根据冠脉病变Gensini评分将冠心病患者分为低评分组(<40分)和高评分组(≥40分)。观察2组血小板参数、胱抑素C(Cystain C)与Gensini评分之间的差异性,明确2组中影响其Gensini评分的因素。采用多因素Logistic回归分析血小板参数、Cystain C与冠脉病变严重程度的关系。结果 2组患者PDW、Cystain C均存在差异(P <0.05)。二元Logistic回归分析显示影响2组患者Gensini评分的多因素主要是PDW、Cystain C(P<0.05)。Cystain C值越大,发生Gensini评分为高评分的可能性越大;PDW值越小,发生Gensini评分为高评分的可能性越大。结论冠心病患者PDW与Cystain C水平为影响冠脉病变严重程度的影响因素,PDW与冠脉病变严重程度存在负相关,Cystain C与冠脉病变严重程度存在正相关。

Objective To explore the correlation between platelet distribution width(PDW),cystatin C and severity of coronary artery disease(CAD)in patients with coronary heart disease(CHD).Methods The clinical data of 896 patients with CHD who underwent coronary angiography in Xinjiang Medical University from August 2016 to October 2017 and met the inclusion criteria were retrospectively analyzed.Patients with CHD were divided into stable angina group(408 cases)and unstable angina group(488 cases)according to their medical history.Patients with CHD were divided into low rating groups(<40 points)and high rating groups(>40 points)according to the Gensini score of CAD.The difference between platelet parameters,cystatin C and Gensini scores in the two groups of stable were observed.Multivariate logistic regression was used to analyze the relationship between platelet parameters,cystatin C and severity of CAD.Results There were significant differences in PDW,cystain C between the two groups(P<0.05).After binary Logistic regression analysis,the multiple factors influencing Gensini score were PDW and cystain C(P<0.05).The higher the value of cystain C,the more likely the Gensini score to be high.The smaller the PDW value,the more likely the Gensini score to be high.Conclusion PDW and Cystain C levels in patients with coronary artery disease are the factors influencing the severity of coronary artery disease,PDW is negatively correlated with the severity of coronary artery disease,and Cystain C is positively correlated with the severity of coronary artery disease.