基于数据挖掘探讨含“桔梗-甘草”药对成方制剂的证治规律

Discussion on Syndrome and Treatment Rules of Set Prescription Preparation Containing Platycodon grandiflorum-Glycyrrhiza uralensis Based on Data Mining

目的:为"桔梗-甘草"药对的临床应用及相关新药研发提供依据。方法:收集《卫生部药品标准·中药成方制剂》中含"桔梗-甘草"药对的所有成方制剂,运用中医传承辅助平台V 2.5对其证治规律进行数据挖掘和分析。结果:共收集到含"桔梗-甘草"药对成方制剂315首,主治证候89种,主治疾病88种。其中,高频主治证候为风热犯表证、风寒束表证,其核心药物组合分别为银翘散和杏苏散;高频主治疾病为感冒、咳嗽,治疗感冒的核心药物组合包含了银翘散、杏苏散、藿香正气散和柴胡枳桔汤等,治疗咳嗽的核心药物组合包含了杏苏散、止嗽散、通宣理肺丸和清金化痰汤等。结论:该研究明确了含"桔梗-甘草"药对成方制剂的证治规律,可为"桔梗-甘草"药对的临床应用和新药研发提供依据。

OBJECTIVE:To provide reference for clinical application and related new drug R&D of the couplet medicines of Platycodon grandiflorum-Glycyrrhiza uralensis.METHODS:All set prescription preparations containing P.grandiflorum-G.uralensis in Ministry of Public Health Drug Standard·TCM Set Prescription Preparation were collected;data mining and analysis for the syndrome and treatment rules of these prescriptions were performed by using TCM Inheritance System V 2.5.RESULTS:There were a total of 315 set prescription preparations containing couplet medicine of P.grandiflorum-G.uralensis,89 main syndromes and 88 main diseases.Among of them,high frequency major syndrome were exterior syndrome attacked by wind-heat and exterior syndrome tightened by wind-cold,and dominating medicine combination were respectively Yinqiao powder and Xingsu powder.High frequency main diseases were common cold and cough.Core medicine combination in the treatment of common cold included Yinqiao powder,Xingsu powder,Huoxiang zhengqi powder and Chaihu zhijie decoction,etc.Core medicine combination in the treatment of cough included Xingsu powder,Zhisou powder,Tongxuan lifei pills and Qingjin huatan decoction,etc.CONCLUSIONS:The study confirms the syndrome and treatment rules of set prescription preparations containing couplet medicines of P.grandiflorum-G.uralensis,and could provide evidence for clinical application of the couplet medicines of P.grandiflorum-G.uralensis and new drug R&D.