男性单相与双相抑郁障碍患者静息态局部脑区低频振幅差异的观察

The amplitude of low-frequency fluctuation of unipolar depression and bipolar depression in male patients: a resting-state functional magnetic resonance study

目的:探讨男性中青年单、双相抑郁障碍患者静息态下局部脑区活动的低频振幅(ALFF)特征。方法:对12例男性单相抑郁患者(单相抑郁组)、12例双相抑郁患者(双相抑郁组)及年龄及受教育程度相匹配的11名男性健康志愿者(健康对照组)进行3. 0 T静息态功能磁共振(fMRI)扫描,计算全脑ALFF值,并进行比较分析。结果:3组间ALFF值在左侧颞中回(-54,-51,9; K=18)、双侧前扣带回(±3,42,15; K=20)比较差异有统计学意义(P均<0. 01,Alphasim矫正);与健康对照组相比,单相抑郁组双侧前扣带回(±3,39,15; K=18) ALFF值显著减少(P均<0. 01),双相抑郁组左侧颞中回(-48,-60,6; K=8;-51,-51,9; K=2) ALFF值显著增加(P均<0. 01);单相抑郁组较双相抑郁组左侧颞中回(-54,-51,9; K=10)和左侧前扣带回(0,42,18; K=16) ALFF值显著减小(P均<0. 01)。结论:男性单、双相抑郁障碍患者静息态下左前扣带回及左侧颞中回活动存在异常,或可作为区分单、双相抑郁障碍的生物学标记。

Objective:To explore the amplitude of low-frequency fluctuation(ALFF)feature of the spontaneous neural activity between young unipolar and bipolar depression male patients,we attempt to find the biological markers to distinguish the two diseases. Method:Twelve unipolar male depression patients(unipolar depression group),12 bipolar male depression patients(bipolar depression group)and 11 age-,educated-matched male healthy controls(healthy control group)were recruited to undergo the 3.0 Tesla resting-state functional magnetic resonance imaging scanning.Calculate the whole brain's amplitude of low-frequency fluctuation and make statistical analyses.Results:The ALFF in the left middle temporal gyrus(-54,-51,9;K=18)and in the bilateral anterior cingulate gyrus(±3,42,15;K=20)among the three groups that had significant differences(all P<0.01,Alphasim).Compared to the healthy control group,the unipolar depression group had significantly lower ALFF in the bilateral anterior cingulate gyrus(±3,39,15;K=18)(all P<0.01);while the bipolar depression group had significantly higher ALFF in the the left middle temporal gyrus(-48,-60,6;K=8;-51,-51,9;K=2)(all P<0.01).And the ALFF in the left middle temporal gyrus(-54,-51,9;K=10)and in the left anterior cingulate gyrus(0,42,18;K=16)were siglifcantly lower in the unipolar depression group compared to the bipolar depression group(all P<0.01).Conclusion:Abnormities exist in the brain regions in unipolar or bipolar depression male patients in the resting state,and the abnormal regions may be the biological markers to distinguish the two diseases.