儿茶酚胺氧甲基转移酶基因rs4680位点多态性与强迫症的关联研究

The study of association between catechol-O-methyltransferase gene polymorphism(rs4680) and obsessive-compulsive disorder

目的:探讨儿茶酚胺氧甲基转移酶(COMT)基因多态性(rs4680)与强迫症的关联性。方法:以山东汉族人群中的400例强迫症患者和459名健康对照者为研究对象,按性别、发病年龄分层,采用MassARRAY飞行时间质谱(MALDI-TOF)技术对COMT基因单核苷酸多态性(SNP)位点rs4680进行基因分型,比较各组等位基因、基因型频率。结果:COMT rs4680位点等位基因和基因型频率在强迫症组和对照组分布差异无统计学意义(P> 0. 05)。按性别、发病年龄分层后,各强迫症组和对照组该位点等位基因和基因型频率分布差异也无统计学意义(P> 0. 05)。结论:COMT基因多态性(rs4680)与强迫症可能不存在关联。

Objective:To investigate the association between Catechol-O-Methyltransferase(COMT)gene polymorphism(rs4680)and obsessive-compulsive disorder(OCD). Method:Using sex,onset age stratification methos,400 cases of obsessive-compulsive disorder and 459 health control subjects in Shandong Han population were enrolled.MassARRAY time-of-flight mass spectrometry(MALDI-TOF)technique was used to genotype COMT gene single nucleotide polymorphism(SNP)Sites rs4680.We compared the distribution frequency of allele and genotype in different groups.Results:There was no statistically significant difference in the distribution of COMT rs4680 allele and genotype frequency in obsessive-compulsive disorder and control Group(P>0.05).After stratified by sex and onset age,there was no statistically significant difference in the allele and genotype frequency distribution between the Obsessive-Compulsive and control groups(P>0.05).Any allele in rs4680 was not found to be a risk factor for the obsessive-compulsive disorder.Conclusion:There may be no association between COMT Gene Polymorphism(rs4680)and obsessive-compulsive disorder.