女性焦虑障碍患者家庭环境、生活事件及甲状腺激素水平的分析

Analysis of family environment,life events and thyroid hormone level of female patients with anxiety disorder

目的:分析女性焦虑障碍患者的焦虑情绪与家庭环境、生活事件及甲状腺激素的关系。方法:采用家庭环境量表、状态-特质焦虑量表、生活事件量表对142例女性焦虑障碍患者及140例健康女性志愿者进行调查;抽取5 ml静脉血检测甲状腺激素水平。结果:女性焦虑障碍患者的状态-特质焦虑量表中焦虑状态(t=17. 69)、焦虑特质评分(t=3. 02)显著高于对照组,差异有统计学意义(P <0. 01);其家庭环境的亲密度(t=6. 86)、独立性(t=3. 75)、娱乐性(t=5. 71)方面分值较对照组低,矛盾性(t=4. 33)、控制性(t=6. 63)分值高于对照组,差异有统计学意义(P <0. 05);女性焦虑障碍患者的负性生活事件(t=12. 05)、家庭有关问题(t=7. 86)、工作学习问题(t=4. 18)等方面分值较对照组高(P <0. 01);女性焦虑障碍患者的血清甲状腺素水平(T4)值高于对照组(t=10. 80,P <0. 00),三碘甲状腺氨酸水平(T3)值低于对照组(t=8. 09,P <0. 00)。结论:女性焦虑障碍患者有明显的焦虑特质,其焦虑与家庭环境密切相关;经历更多的负性生活事件,甲状腺激素水平增高。

Objective:To investigate relationship between anxiety disorder of female patients and family environment,life events and thyroid hormone level. Method:142 female patients with anxiety disorder and 140 health female volunteers were assessed by the Chinese version of the family environment scale(FES-CV),state-trait anxiety inventory(STAI),Life event scale(LES).Serum level of FT3,FT4,T3,T4,TSH between the two groups were tested and compared.Results:The scores of anxiety state(t=17.69)and anxiety trait(t=3.02)of study group were higher than that of control group,the difference was statistically significant(P<0.01).The scores of intimacy(t=6.86),independence(t=3.75),entertainment(t=5.71)of study group were lower than that of control group,while the scores of conflicts(t=4.33),control(t=6.63)in the study group were higher than those in the control group(P<0.05).The negative events value(t=12.05,P<0.00)in the study group was significantly higher than those in the control group.The T4 value of the study group was higher than that of the control group(t=10.80,P<0.00),while the T3 value was lower than that of the control group(t=8.09,P<0.00).Conclusion:The female patients with anxiety disorder had significant anxiety trait,their anxiety were closely related with the family environment.And they had experienced more negative events and increased thyroid hormone levels.