血清CK-MB、MB、cTnⅠ联合检测在中老年急性心肌梗死患者早期诊断中的应用价值

Application value of CK-MB,MB,cTnⅠ joint detection on the early diagnosis of middle-aged patients with acute myocardial infarction

目的分析血清肌酸激酶同工酶(CK-MB)、血清肌红蛋白(MB)、肌钙蛋白-Ⅰ(cTnⅠ)联合检测在中老年急性心肌梗死(AMI)早期诊断中的应用价值。方法回顾性分析2016年9月至2017年9月濮阳市眼科医院收治的220例疑为AMI患者的临床资料,根据最终诊断分为AMI组(152例)和非AMI组(68例)。比较两组患者CK-MB、MB、cTnⅠ水平差异及AMI组不同时段各指标变化,并比较3指标单独检测和联合检测的诊断符合率。结果 AMI组CK-MB、MB、cTnⅠ水平高于非AMI组(P<0.05); AMI组发病后12 h内CK-MB、MB、cTnⅠ水平变化比较,差异有统计学意义(P<0.05); AMI组MB、cTnⅠ单独诊断符合率高于CK-MB(P<0.05);非AMI组CK-MB、MB、cTnⅠ单独诊断符合率比较,差异无统计学意义(P>0.05);两组联合检测诊断符合率均高于CK-MB、MB、cTnⅠ单独检测(P<0.05)。结论血清CK-MB、MB、cTnⅠ联合检测有利于提高中老年AMI患者的诊断符合率,临床应用价值可观。

Objective To investigate the application value of creatine kinase MB(CK-MB),myoglobin(MB),cardiac troponin-Ⅰ(cTnⅠ)joint detection on the early diagnosis of middle-aged patients with acute myocardial infarction(AMI).Methods The clinical data of 220 cases with AMI in the Eye Hospital of Puyang City from September of 2016 to September of 2017 were retrospectively analyzed.The patients were divided into the AMI group(152 cases)and the non AMI group(68 cases)according to the final diagnosis.The CK-MB,MB,cTnⅠlevel differences between the two groups and index changes at different time period in the AMI group were compared.The diagnose accordance rate of the three indexes detection alone and the joint detection were compared.Results CK-MB,MB,cTnⅠlevels of the AMI group were higher than those of the non AMI group(P<0.05).Within 12 h after onset,the difference of CK-MB,MB,cTnⅠlevel changes had statistic significance(P<0.05).In the AMI group,coincidence rate of MB,cTnⅠdiagnosis alone was higher than CK-MB(P<0.05).In the non AMI group,the difference of the coincidence rate of CK-MB,MB,cTnⅠdetection alone had no statistic significance(P>0.05).The coincidence rate of joint detection was higher than CK-MB,MB,cTnⅠdetection alone in the two groups(P<0.05).Conclusion CK-MB,MB,cTnⅠjoint detection is benefit for improving the diagnosis coincidence rate of middle-aged patients with AMI,and it has significant clinic application value.