米非司酮与孕激素治疗围绝经期功能失调性子宫出血的比较

Comparison of Mifepristone and Progesterone in the Treatment of Perimenopausal Dysfunctional Uterine Bleeding

目的探讨米非司酮与孕激素治疗围绝经期功能失调性子宫出血的比较。方法选取我院2016年1月至2017年1月接收的围绝经期功能失调性子宫出血的100例患者作为研究对象,按照数字抽签法分为两组,对照组患者服用炔诺酮,观察组患者空腹服用米非司酮,观察其临床疗效。结果两组患者治疗后的月经周期、治疗前后血红蛋白之间没有差异性(P>0.05);观察组患者治疗后的经期显著短于对照组,差异明显(P<0.05);观察组患者复发率为4.0%(2/50),对照组患者复发率为24.0%(12/50),相比存在差异性(P<0.05),有统计学意义。结论围绝经期的患者采用米非司酮治疗后的月经期相比于炔诺酮治疗显著缩短,减少复发率。

Objective To investigate the comparison of mifepristone and progesterone in the treatment of perimenopausal dysfunctional uterine bleeding.Methods A total of 100 patients with perimenopausal dysfunctional uterine bleeding were selected as the subjects.The patients were divided into two groups according to the digital lottery method.The patients in the control group were treated with norethindrone.The patients in the observation group were treated with mifepristone,To observe its clinical efficacy.Results There was no difference in hemoglobin between the two groups before and after treatment(P>0.05).The recurrence rate of the observation group was significantly shorter than that of the control group(P<0.05)4.0%(2/50),the recurrence rate was 24.0%(12/50)in the control group,which was statistically significant(P<0.05).Conclusion Perimenopausal patients with mifepristone after menstrual period compared to norethindrone treatment significantly shortened,reducing the recurrence rate.