彩色多普勒超声联合MRI诊断胎儿胼胝体发育不全临床分析

Clinical analysis of color Doppler ultrasound combined with MRI in the diagnosis of fetal agenesis of the corpus callosum

目的探讨彩色多普勒超声联合核磁共振成像(MRI)对胎儿胼胝体发育不全的诊断价值。方法选择2014年2月至2017年5月在该院行产前超声畸形筛查疑似胎儿胼胝体发育不全的95例胎儿为研究对象,均接受彩色多普勒超声和MRI检查。以出生后影像学检查结果或引产后尸检结果为金标准,比较单一彩色多普勒超声检查和联合MRI检查的诊断准确率。结果影像学检查或尸检结果显示,95例中60例为胼胝体发育不全,其中完全、部分型胼胝体发育不全分别为40、20例;彩色多普勒超声联合MRI对胎儿完全型胼胝体发育不全的诊断准确率为95.00%(38/40),高于单一彩色多普勒超声检查的77.50%(31/40),差异有统计学意义(P<0.05);彩色多普勒超声联合MRI对胎儿部分型胼胝体发育不全的诊断准确率与单一彩色多普勒超声检查比较,差异无统计学意义(P>0.05);彩色多普勒超声联合MRI对胎儿胼胝体发育不全的诊断准确率为95.00%(57/60)高于单一彩色多普勒超声检查的81.67%(49/60),差异有统计学意义(P<0.05)。结论采用彩色多普勒超声联合MRI检查能提高对胎儿胼胝体发育不全的诊断准确率,可将MRI作为彩色多普勒超声检查的有利补充和验证手段。

Objective To investigate the value of color Doppler ultrasound(CDUS)combined with magnetic resonance imaging(MRI)in the diagnosis of fetal agenesis of the corpus callosum(ACC).Methods Ninety-five fetals with suspected ACC who received prenatal ultrasound deformity screening in this hospital from February 2014 to May 2017 were enrolled in this study.All the fetals were given CDUS and MRI.The imaging results after birth or autopsy results after induced labor was taken as the gold standard.The diagnostic accuracy of single CDUS and CDUS combined with MRI were compared.Results The imaging results after birth or autopsy results showed:there were 60 cases of ACC,including 40 cases of complete ACC and 20 cases of partial ACC;The diagnostic accuracy of CDUS combined with MRI in the complete ACC was 95.00%(38/40),which was higher than single CDUS[77.50%(31/40),P<0.05];The diagnostic accuracy of CDUS combined with MRI in the partial ACC was compared with that of single CDUS,there was no statistical difference(P>0.05);The diagnostic accuracy of CDUS combined with MRI in the fetal ACC was 95.00%(57/60),which was higher than single CDUS[81.67%(49/60),P<0.05].Conclusion CDUS combined with MRI can increase the diagnostic accuracy of fetal ACC,so that MRI can be used as advantageous complement for CDUS.