高定义角度纤维追踪技术重建人脑颞顶枕区短纤维束连接

Reconstruction of short associative white fibers in human temporo-parieto-occipital area using high-definition fiber tracking tractography

目的观察人脑颞顶枕区短纤维束连接的空间走行、皮质连接及三维空间关系。方法对10名健康志愿者进行MR扫描。下载90名健康志愿者的弥散谱成像(DSI)综合数据模板(NTU-90)。应用高定义角度纤维束追踪技术(HDFT)对所收集数据进行人脑颞顶枕区3条短纤维束连接[上纵束的垂直部(SLF-V)、枕纵束(VOF)和颞顶束(TP)]重建,并分析其纤维走行、皮质连接、空间三维关系及左右侧别差异。结果 3条纤维束在10名志愿者和NTU-90中均重建成功。SLF-V纤维束起源于颞中回和颞下回后部,终止于角回和缘上回;VOF纤维束起源于下枕叶和梭状回,少量纤维来源于颞下回的后部和枕极前部,终止点位于角回和上枕叶外侧部;TP纤维束主要起源于颞中回、颞下回、梭状回和下颞-下枕结合部,连接于顶上小叶;左右侧SLF-V、VOF和TP的纤维束体积差异无统计学意义(P均>0.05)。结论应用HDFT纤维束成像技术成功重建了SLF-V、VOF和TP,可为脑功能研究和神经外科手术提供解剖学依据。

Objective To reconstruct the pathways,cortex connections and three-dimensional architectures of short associative tracts in human temporo-parieto-occipital(TPO)area using high-definition fiber tracking(HDFT)tractography.Methods Ten healthy subjects underwent MR scan,and template integrating diffusion spectrum imaging(DSI)data of 90 healthy subjects(NTI-90)were analyzed.Then three short associative white fibers in the TPO area(superior longitudinal fasciculus-V[SLF-V],vertical occipital fasciculus[VOF]and temporo-parietal connection[TP])were reconstructed.The pathways,cortex connections and three-dimensional architectures of these tracts were evaluated,as well as the volumes of the tracts.Results Three short associative tracts were all identified in 10 subjects and NTI-90 template.The SLF-V originated from the posterior part of the middle temporal gyrus and inferior temporal gyrus,terminating the angular gyrus and supramarginal gyrus.The VOF ascended from the inferior occipital lobe and fusiform gyrus,while some from the posterior part of the inferior temporal gyrus and front of the occipital pole,and the cortical endpoints were in the angular gyrus and lateral part of the superior occipital lobe.The TP connection mainly arose from the inferior temporal gyrus,middle temporal gyrus,fusiform gyrus,and some also from the inferior temporal gyrus-inferior occipital lobe junction areas.The projection of the TP connection sloped upwards to the superior parietal lobe.There was no significant difference of volumes of these three tracts(all P>0.05).Conclusion SLF-V,VOF and TP are successfully reconstructed using HDFT tractography with more complete connectivity patterns,therefore providing anatomy evidences for brain function study and neurosurgery approach.