FKBP1B基因对心脑血管系统作用的研究进展

Progress of research on FKBP1B gene in cardiovascular and cerebrovascular systems

FK506结合蛋白1B(FK506 binding proteins 1B,FKBP1B)是FKBPs家族中的一员,主要在心肌、脑组织和平滑肌等组织中表达。近年来,关于FKBP1B在心脏和神经系统中所承担的作用受到更多关注,而大量实验也证实FKBP1B参与心脏发育、疾病发生以及大脑衰老、神经功能障碍等重要机体活动。但FKBP1B在心脑血管系统中以何种方式和机制进行调控尚不明确。研究发现FKBP1B无论是在心肌还是脑组织中,都能通过与RyR2受体结合来控制Ca^(2+)的释放。本文就FKBP1B在心脏和脑组织中所发挥功能和调控机理做一综述,为深入了解心脑血管系统生理和病理机制提供理论依据。

FK506 binding protein 1B(FKBP1B),a member of the FKBP family,is mainly expressed in myocardium,brain tissue,and smooth muscle.Its roles in the heart and nervous system have received increasing attention in recent years,and a number of experiments have confirmed FKBP1B’s involvement in important physiological activities in heart development,disease,brain aging,and nerve dysfunction.Thus,the regulatory mechanisms and mechanisms of action of FKBP1B in the heart and brain have become matters of increasing importance.Through continuous exploration,FKBP1B has been found to be able to control Ca 2+release by binding to RyR2 receptors in both myocardium and brain tissue.This article reviews FKBP1B’s functions and regulatory mechanisms in heart and brain tissue in order to provide a theoretical basis for understanding the physiological and pathological mechanisms of the cardiovascular and cerebrovascular systems in the fight against human diseases.