女性阿尔茨海默病患者静息态功能磁共振图像FC分析

Functional connectivity analysis of resting state functional magnetic resonance imaging in female patients with Alzheimer's disease

利用静息态功能磁共振对阿尔茨海默病(Alzheimer disease,AD)患者发病机制和病理过程的研究结果表明AD患者脑功能的改变早于脑结构的改变,女性患病率是男性的2倍.针对不同年龄段女性患者静息态功能磁共振成像(resting-state functional magnetic resonance imaging,rs-fMRI),基于SPM(statistical parametric mapping,SPM)对图像进行时间上的时间层校正以消除时间差;空间上的头动校正、归一化、平滑等操作降低个体间差异.采用独立分量分析(independent component analysis,ICA)及聚类等方法进行盲源分离和稳定性分析,通过统计检验及组间对比研究女性患者各脑区之间的连接关系及其强弱,进而判断功能连接(functional connectivity,FC)差异,为女性AD患者临床前期诊断提供参考.

The studies on the pathogenesis and pathological process of Alzheimer s disease by resting state functional magnetic resonance show that changes in brain function of AD patients are earlier than changes in brain structure,and the prevalence rate of females is twice than that of males.According to the rs-fMRI for females of different ages,time layer correction is performed on the image based on SPM to eliminate the elimination of time difference;Head motion correction,normalization and smooth skating in space reduces the difference between indiv iduals.The blind source separation and stability analysis were carried out by the methods of independent component analysis(ICA)and clustering.The connection and strength of the brain regions of female patients were studied by statistical test and comparison,and then the difference of functional connectivity(FC)was judged,which provide reference for females AD patients in preclinical diagnosis.