后循环TIA患者临床认知功能与P300相关性研究

Relationship between clinical cognitive function and ERP/P300 of PI-TIA patients

目的探讨后循环(posterior circulation,PI)-短暂性脑缺血发作(transient ischemic attack,TIA)患者大脑认知功能的临床表现,了解PI-TIA患者大脑认知功能状态。方法选择2011年7月-2012年8月在新疆石河子市人民医院神经内科住院的PI-TIA患者30例,对照组50例。两组患者使用简易精神状态量表(MMSE)、蒙特利尔认知评估中文版(M0CA)和事件相关电位P300(ERP/P300)进行认知功能评定。结果 PI-TIA组MoCA和MMSE评分较对照组减低(P <0. 01); P300潜伏期较对照组延长(P <0. 01)。PI-TIA组MoCA子项目中执行功能/视空间、命名、记忆评分较对照组低(P <0. 01,0. 05)。PI-TIA组MMSE子项目时间定向力、语言即刻记忆、计算能力、短程记忆、语言表达、图形描画评分较对照组低(P <0. 01,0. 05)。MMSE和MoCA正相关(r=0. 811,P <0. 01)。MMSE和P300潜伏期负相关(r=-0. 745,P <0. 01)。结论 PI-TIA患者存在一定的认知功能损害。MoCA和P300潜伏期可识别PI-TIA患者早期认知功能损害。

Objective To provide the evaluation for the early cognitive impairment with patients of PI-TIA.Methods 30 patients who were treated in our hospital from July 2011 to August 2012 and 50 healthy controls were enrolled.The mini-mental state examination(MMSE),Montreal cognitive assessment(MoCA)and Event-related potential(ERP)/P300 were used to evaluate the cognitive function in 2 groups.Results PI-TIA patients compared with healthy controls of P300 latency and amplitude and MoCA scores were statistically significant difference(P<0.05,0.01).The scores were lower in the PI-TIA patients group on the executive function,visual space,naming,memory,directional(P<0.01,0.05).MMSE compared with MoCA and P-300 latency of Kappa value is 0.705 and 0.661(P<0.01).Conclusion The PI-TIA patients have cognitive impairment.MoCA and P300 latency provides higher sensitivity and specificity than MMSE in screening cognitive impairment in PI-TIA patients.