摘要
TWIK相关酸敏感钾离子通道(TASK)-1和TASK-3是双孔钾离子通道家族的重要成员,广泛表达于中枢神经系统和外周组织,对缺氧和细胞外液p H值变化极为敏感。TASK参与呼吸中枢的表达及呼吸运动的调节,同时在睡眠调节中也可发挥一定作用,本文总结了TASK在呼吸与睡眠调节中的相关研究进展。
TWIK-related acid-sensitive K+channel(TASK)is an important member of the two-pore-domain potassium channels family.It is widely expressed in the central nervous system and peripheral tissues and is extremely sensitive to hypoxia and pH changes in extracellular fluid.TASK participates in regulating the expression of respiratory center and the respiratory movement and also plays certain role in sleep regulation.This article reviews the recent advances in the roles of TASK in the regulation of respiration and sleep.
作者
张德莲
史甜
姚晓光
李南方
闻璐
ZHANG Delian;SHI Tian;YAO Xiaoguang;LI Nanfang;WEN Lu(Institute of Hypertension of Xinjiang Uygur Autonomous Region,Center for Hypertension of the People’s Hospital of Xinjiang Uygur Autonomous Region,Urumqi 830001,China)
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
2018年第5期694-698,共5页
Acta Academiae Medicinae Sinicae
基金
国家自然科学基金(81650002)。
