LOX-1和Vaspin在冠心病患者体内的表达及其与PCI术后再狭窄的关系

Relationship of LOX-1 and Vaspin with restenosis after PCI in patients with coronary artery disease

目的:探讨血凝素氧化低密度脂蛋白受体-1 (LOX-1)和内脏脂肪特异性丝氨酸蛋白酶抑制剂(Vaspin)在冠心病患者体内的表达及其与经皮冠状动脉介入(PCI)术后再狭窄的相关性。方法:回顾性分析2013年10月至2016年7月185例在我院行PCI术患者的临床资料,其中男125例,女60例,年龄29～78岁,平均(60. 35±10. 04)岁。根据其术后再狭窄情况分为非狭窄组(129例)与再狭窄组(56例)。收集患者性别、年龄、高血压、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、糖尿病以及吸烟方面的资料。冠状动脉病变狭窄严重程度采用Gensini积分进行评价。用酶联免疫法测定患者体内LOX-1和Vaspin水平,并分析LOX-1和Vaspin水平与PCI术后再狭窄的关系。结果:与非狭窄组比较,再狭窄组中高LDL-C、低HDL-C以及有吸烟史的比例较高,差异有统计学意义(均P <0. 05)。再狭窄组LOX-1水平明显高于非狭窄组,Vaspin水平却明显低于非狭窄组(均P <0. 05)。再狭窄组LOX-1水平与Gensini积分呈正相关(r=0. 316,P=0. 003),Vaspin水平与Gensini积分呈负相关(r=-0. 284,P=0. 007)。LOX-1 (OR=1. 876,95%CI 1. 452～2. 345)、Vaspin(OR=1. 755,95%CI 1. 430～2. 486)均为PCI术后再狭窄的独立危险因素。结论:Gensini积分与LOX-1水平呈正相关,与Vaspin水平呈负相关。体内LOX-1和Vaspin水平均为PCI术后再狭窄的独立危险因素,应予以重视。

Objective:To study the relationship of LOX-1 and Vaspin with restenosis after PCI in patients with coronary artery disease.Methods:Patients with coronary artery disease were retrospectively analyzed,who were admitted to our hospital between October 2013 and July 2016.They were distributed into 2 groups according to the results of restenosis after PCI,including 129 cases of non-restenosis after PCI and 56 cases of restenosis after PCI.Basic situations of the gender,hypertension,high cholesterol,diabetes,and smoking in each patients were analyzed.The severity of coronary artery stenosis was assessed using Gensini integral.The levels of LOX-1 and vaspin in the patients were measured by enzyme-linked immunosorbent assay,and the relationship between LOX-1 and serum vaspin levels and restenosis after PCI was investigated.Results:The proportion of high LDL-C,low HDL-C and smoking history was higher in the restenosis group compared with the non-stenosis group(all P<0.05).The level of LOX-1 in restenosis group was significantly higher than that in non-stenosis group,while the level of Vaspin in restenosis group was significantly lower than that in non-stenosis group(all P<0.05).LOX-1 level was positively correlated with Gensini score(r=0.316,P=0.003)in restenosis group,Vaspin level was negatively correlated with Gensini score(r=-0.284,P=0.007).LOX-1(OR=1.876,95%CI 1.452-2.345)and Vaspin(OR=1.755,95%CI 1.430-2.486)were independent risk factors for restenosis after PCI.Conclusion:Gensini score is positively correlated with LOX-1 and negatively correlated with Vaspin.In vivo LOX-1 and Vaspin levels are independent risk factors for restenosis after PCI.