调节性T细胞参与胰腺癌免疫微环境重塑的基础与转化研究进展

Advances of basic and clinical translational research on the role of Treg cells in immune microenvironment remodeling in pancreatic cancer

调节性T细胞(regulatory T cells/Treg cells)是发挥负性免疫调节功能的一类CD4^+T细胞,主要通过抑制多种效应性T细胞的活性和功能,维持机体获得性免疫系统的平衡,防止自身免疫性疾病的发生。Treg细胞也是免疫抑制性肿瘤微环境的主要组成成分,其在肿瘤局部微环境中,对抗肿瘤免疫应答过程,发挥免疫抑制作用,并协助肿瘤细胞参与免疫逃逸,进而影响肿瘤的恶性演进过程。本文对Treg细胞在胰腺癌免疫微环境重塑过程中发挥功能的机制及其临床转化研究进展进行综述,旨在加深对胰腺癌免疫抑制微环境的认识,为胰腺癌的免疫调节治疗提供新思路。

Regulatory T(Treg)cells are a class of immune cells characterized with CD4+that exert negative immunomodulatory effects.By inhibiting the activity of effector T cells,they maintain the balance of the body's adaptive immune system to prevent the occurrence of autoimmune diseases.Treg cells,the main components of the immunosuppressive tumor microenvironment,also inhibit the immune response of effector T cells in the local tumor immune microenvironment and promote immunosuppression and tumor cell immune evasion,thereby facilitating the malignant evolution of the tumor.Aimed at prompting the understanding of the immunosuppressive microenvironment of pancreatic cancer,this review will systematically summarize the functional mechanisms of Treg cells in immune microenvironment remodeling in pancreatic cancer and the latest developments in clinical translational research,which may provide a new strategy for immune regulation therapy.