持续不卧床腹膜透析患者蛋白质-能量消耗与同型半胱氨酸关系的探讨

Relationship between protein energy expenditure and homocysteine in Continuous ambulatory peritoneal dialysis patients

目的:探讨持续不卧床腹膜透析(CAPD)患者蛋白质-能量消耗(PEW)与血同型半胱氨酸水平(Hcy)的关系。方法:收治CAPD患者82例,根据血Hcy水平分为A组、B组。结果:两组改良主观全面营养评估(MQSGA)积分、血白蛋白(ALB)、前白蛋白(PA)、C反应蛋白(CRP)比较,差异有统计学意义(P<0.05);A组治疗前后Hcy、MQSGA积分、血白蛋白(ALB)、前白蛋白(PA)、CRP比较差异有统计学意义(P<0.05);Hcy与MQSGA、CRP呈正相关(r=0.371,r=0.331,P<0.05)。结论:持续不卧床CAPD患者普遍存在高同型半胱氨酸血症,血同型半胱氨酸水平对蛋白质-能量消耗的评估及诊治具有一定意义。

Objective:To explore the relationship between protein energy expenditure(PEW)and homocysteine(HCY)in Continuous ambulatory peritoneal dialysis patients(CAPD).Methods:82 patients with CAPD were selected,they were divided into the A group and the B group according to HCY level.Results:The scores of improved subjective comprehensive nutrition assessment(MQSGA),serum albumin(ALB),prealbumin(PA)and C-reactive protein(CRP)were significantly different between the two groups(P<0.05).There were significant differences in HCY,MQSGA score,serum albumin(ALB),prealbumin(PA)and CRP before and after treatment in the A group(P<0.05).HCY was positively correlated with MQSGA and CRP(r=0.371,r=0.331,P<0.05).Conclusion:Hyperhomocysteinemia was common in CAPD patients,blood homocysteine level had a certain significance in the evaluation and diagnosis of protein energy expenditure.