血清中胃蛋白酶原Ⅰ、Ⅱ含量变化与慢性萎缩性胃炎及胃癌发生的关系

Relationship between changes of serum pepsinogen Ⅰ and Ⅱ levels and chronic atrophic gastritis and gastric cancer

目的:讨论血清中胃蛋白酶原Ⅰ、Ⅱ含量变化与慢性萎缩性胃炎及胃癌发生的关系。方法:收治慢性萎缩性胃炎及胃癌患者40例,纳入观察组;选取同时期健康志愿者20例作对照组。检测两组患者血清中胃蛋白酶原(PG)的含量。结果:观察组患者血清中PGⅠ含量与对照组进行比较明显降低,胃癌患者血清中PGⅠ、PGⅡ含量与慢性萎缩性胃炎患者进行比较明显较低(P<0.05)。结论:慢性萎缩性胃炎以及胃癌患者血清中PGⅠ、PGⅡ含量明显低于健康志愿者,可作为这类疾病的诊断方法。

Objective:To discuss the relationship between the changes of serum pepsinogenⅠandⅡlevels and the occurrence of chronic atrophic gastritis and gastric cancer.Methods:40 patients with chronic atrophic gastritis and gastric cancer were enrolled in the observation group and 20 healthy volunteers were selected as the control group,we detected serum pepsinogen(PG)in the two groups of patients.Results:The serum PGⅠlevels in the observation group were significantly lower than those in the control group.The serum levels of PGⅠand PGⅡin patients with gastric cancer were significantly lower than those in patients with chronic atrophic gastritis(P<0.05).Conclusion:The serum levels of PGⅠand PGⅡin patients with chronic atrophic gastritis and gastric cancer are significantly lower than those in healthy volunteers,which can be used as a diagnostic method for this kind of disease.