我院613例药品不良反应报告分析

Analysis of 613 cases of adverse drug reaction in our hospital

目的分析我院药品不良反应(adverse drug reactions,ADR)发生的特点与规律,为加强我院ADR监测和临床安全用药提供借鉴。方法按照患者的性别、年龄,给药途径,ADR的类型、发生时间,引发ADR的药品,ADR所累及器官或系统等,对我院2017年613例ADR报告进行统计分析。结果 613例ADR中,女性占51. 55%,中青年(18-60岁)占75. 04%。静脉给药ADR发生率最高,为54. 98%。613例ADR共涉及315种药品,其中西药最多,占79. 68%,西药中抗感染药物占31. 32%。ADR所累及的器官或系统中,皮肤及其附件损害最多,占26. 71%,其次为胃肠道损害,占25. 69%。结论药品不良反应的发生受多个因素的影响,会累及多个器官或系统,在临床药物治疗过程中应加强药品不良反应的监测,以降低用药风险。

Objective To analyze the characteristics and regularities of adverse drug reactions(ADR)in our hospital,and to provide a reference for strengthening the monitoring of ADR and clinical safe medication.Methods Totally 613 cases of ADR in 2017 in our hospital were analyzed statistically according to patients’gender and age,route of administration,types and occurrence time of ADR,ADR-inducing drugs,organs or systems involved in ADR and so on.Results Among 613 cases of ADR,female accounted for 51.55%,and young and middle-aged ones(18-60 years old)accounted for 75.04%.ADR induced by intravenous administration had the highest incidence,accounting for 54.98%.A total of 315 kinds of drugs were involved in 613 cases of ADR.Most of the ADR-inducing drugs was the western medicine(79.68%),in which the anti-infective drugs accounted for 31.32%.The main organs or systems involved in ADR were the skin and its appendents(26.71%),followed by gastrointestinal system(25.69%).Conclusion The adverse drug reactions are associated with many factors and might involve multiple organs or systems,thus the monitoring of ADR should be strengthened in the course of clinical drug treatment to reduce the risk of drug use.