丹参川芎嗪联用阿托伐他汀对PCI术后ACS病人血清胱抑素C与炎症因子的影响

Effects of Danshen-tetramethylpyrazine Injection and Atorvastatin on Serum Cystatin C and Inflammatory Factors in Patients with Acute Coronary Syndrome after PCI

目的探讨丹参川芎嗪联用阿托伐他汀对急性冠脉综合征(ACS)病人经皮冠状动脉介入治疗(PCI)术后血清胱抑素C(Cys C)与炎症因子的影响。方法选取2014年2月—2017年2月行PCI术的ACS病人174例,根据治疗方案不同将其分为3组。试验对照组(55例)给予口服阿司匹林和氯吡格雷常规治疗,试验A组(61例)在对照组基础上加用口服阿托伐他汀治疗,试验B组(58例)在试验A组基础上加用丹参川芎嗪静脉输注治疗。各组均连续治疗2周,检测各组治疗前后血清胱抑素C、白细胞介素-6(IL-6)、超敏C反应蛋白(hs-CRP)与肿瘤坏死因子-α(TNF-α)水平。结果治疗2周后,Cys C与IL-6、hs-CRP、TNF-α水平均为试验B组<试验A组<试验对照组,差异有统计学意义(P <0.05)。结论丹参川芎嗪联合阿托伐他汀可有效抑制PCI术后炎症反应,改善炎症因子表达。

Objective To investigate the influence of Danshen Chuanqiongqin injection(DCI)and atorvastatin on serum Cystatin C(Cys C)and inflammatory factors levels in patients with acute coronary syndrome(ACS)after percutaneous coronary intervention(PCI).Methods One hundred and seventy four patients with ACS after PCI in the hospital from Feb 2014 to Feb 2017 were randomly divided into 3 groups:control group(n=55)treated with aspirin and clopidogrel,test group A(n=61)treated with aspirin,clopidogrel and atorvastatin,and test group B(n=58)treated with aspirin,clopidogrel,atorvastatin and DCI for 2 weeks.After 2 weeks of treatment,the serum Cys C and inflammatory factors such as interleukin 6(IL 6),high sensitivity C reactive protein(hs CRP)and tumor necrosis factorα(TNFα)levels were measured before and after treatment.Results After 2 weeks of treatment,the levels of Cys C and IL 6,hs CRP and TNFαwere lower in the test group B than that in test group A and control group,which were lower in the test group A than that in control group(P<0.05).Conclusion DCI and atorvastatin can effectively inhibit the inflammatory reactions and decrease the levels of the expression of inflammatory factors in patients with ACS after PCI.