力学刺激介导氧化应激效应在疾病发生发展中的生物学机制

Biological mechanism of oxidative stress induced by mechanical stimulation in the development of diseases

背景:力学刺激和氧化应激在机体生理病理过程中均发挥着重要作用,各受力系统中力学环境的改变可能会引发一系列疾病的发生发展。目的:以肺组织及心血管系统为代表,对力学刺激与氧化应激及相关疾病之间的关系进行综述。方法:由第一作者检索PubMed数据库、CNKI数据库、万方数据库、SpringerLink、ScienceD irect等2001至2017年收录的,关于力学环境和氧化应激在肺组织损伤及心血管疾病发生发展中的相关文献。英文检索词为"mechanical stimulation,oxidative stress,lung injury,cardiovascular disease",中文检索词为"力学刺激,氧化应激,肺损伤,心血管疾病",按纳入、排除标准筛选最终纳入61篇文献进行分析、总结。结果与结论:异常力学刺激会引起肺上皮细胞、血管内皮细胞及血管平滑肌细胞等多种类型细胞中活性氧自由基的过度释放,并通过一系列信号途径,造成细胞凋亡、细胞通透性增加及炎症反应等,最终导致肺损伤和动脉粥样硬化等心血管疾病的发生。探讨力学刺激介导的氧化应激反应及其分子生物学机制,可为人们更好地理解相关疾病的发生发展机制及其预防和治疗提供新思路和新靶点。

BACKGROUND:Mechanical stimulation and oxidative stress play an important role in the physiological and pathological processes in vivo.Changes of mechanical environment in each mechanical system may lead to occurrence and development of a series of diseases.OBJECTIVE:To summarize the relationship between mechanical stimulation and oxidative stress in related diseases,in lung tissue and cardiovascular system.METHODS:A computer-based search of PubMed,CNKI,WanFang,SpringerLink,and ScienceDirect databases was performed for relevant literature addressing the mechanical environment and oxidative stress in the development of lung tissue injury and cardiovascular disease published from 2001 to 2017.The keywords were“mechanical stimulation,oxidative stress,lung injury,cardiovascular disease”in English and Chinese,respectively.According to the inclusion and exclusion criteria,61 eligible articles were included for further analysis and summary.RESULTS AND CONCLUSION:Abnormal mechanical stimulation can cause excessive release of reactive oxygen species in lung epithelial cells,vascular endothelial cells,vascular smooth muscle cells and other types of cells,which results in cell apoptosis,increased cell permeability and the inflammatory response through a series of signal cascade,eventually leading to lung injury and cardiovascular diseases such as atherosclerosis.Exploring the oxidative stress induced by mechanical stimulation and its possible molecular mechanisms will not only contribute to understanding the mechanisms of related diseases,but also provide new insights and targets for the prevention and treatment of diseases in the clinic.