膀胱癌淋巴结转移评估的生物学研究进展

The biological research brogress in evaluation of lymph Node Metastasis in bladder cancer

淋巴转移途径是膀胱癌的早期转移方式,其转移与否决定手术方案并影响患者的远期生存。近年来,关于分子生物学预测膀胱癌分期的综述文献有之,但关于生物学评估淋巴结转移的综述文献报道较少。分子生物学可从基因水平、分子水平和细胞组织水平,不仅能微观而早期的评估膀胱癌淋巴结的转移情况,而且能从基因表达和蛋白质的翻译过程,以及细胞组织的形态和功能改变,多层面多指标的评估其转移情况。文章从基因、分子及细胞组织水平对膀胱癌淋巴结转移的评估指标作一综述。

Invasion and metastasis are the main behavior of malignant tumors.Lymph node metastasis is an early metastasis mode of bladder cancer,which is an important risk factor for poor prognosis.It is also an important index to decide the treatment,especially to determine the operation mode and strategy.Therefore,searching for the evaluation index of lymph node metastasis of malignant tumor is the focus of tumor research.In recent years,the literature of molecular biology for predicting the staging of bladder cancer has been reviewed,but the literature on biological assessment of lymph node metastasis hasn′t.At present,many evaluation indexes related to lymph node metastasis of bladder cancer have been reported in addition to the new imaging methods,from gene to protein,and then to cell and tissue.In this paper,we try to look into the biological research progress in the evaluation of lymph node metastasis of bladder cancer.