针刺四缝穴治疗小儿厌食症疗效和安全性的Meta分析

Efficacy and safety of acupuncture at point EX-UE10 for infantile anorexia:a Meta-analysis

目的系统评价针刺四缝穴治疗小儿厌食症的疗效和安全性。方法计算机检索PubMed、EMbase、The Cochrane Library、CNKI、CBM和WanFang Data数据库,搜集针刺四缝穴对比西医常规药物治疗方法治疗小儿厌食症的随机对照试验,检索时限从建库至2018年1月。由2位研究者独立筛选文献、提取资料和评价纳入研究的偏倚风险后,采用RevMan5.3软件对数据进行Meta分析。结果共纳入8个研究,包括737例患者。Meta分析结果显示:与对照组相比,单纯针刺四缝穴治疗小儿厌食症的总有效率更高,其差异有统计学意义[OR=4.37,95%CI(2.87,6.66),P<0.000 01],且纳入的8个研究中,均未报告试验组出现明显不良反应。结论针刺四缝穴治疗小儿厌食症疗效显著,其简便易行,且安全性高,值得临床推广。但受纳入研究的数量和质量限制,上述结论尚需更多高质量研究予以验证。

Objective To systematically review the efficacy and safety of acupuncture at point EX-UE10 for patients with infantile anorexia.Methods PubMed,EMbase,The Cochrane Library,CNKI,CBM and WanFang Data databases were electronically searched to collect the randomized controlled trials about acupuncture at point EX-UE10 versus conventional drugs for patients with infantile anorexia from inception toJanuary,2018.Two reviewers independently screened the literature,extracted the data and assessed the risk of bias of included studies,and meta-analysis was then performed using RevMan 5.3 software.Results A total of 8 studies involving 737 patients with infantile anorexia were included.Meta-analysis showed that:compared with the control group,acupuncture at point EX-UE10 was more effective in treating infantile anorexia,and there was significant difference between two groups[OR=4.37,95%CI(2.87,6.66),P<0.000 01];in the eight studies included,no significant adverse reactions were reported with the experiment group.Conclusion The treatment of acupuncture at point EX-UE10 is effective for patients with infantile anorexia,and is simple and easy to operate with high safety,so it is worthy of wide use in clinics.Due to limited quantity and quality of the included studies,the above conclusion needs to be further verified by more high quality studies.