清肺平喘汤对呼吸道合胞病毒肺炎(痰热闭肺型)患儿潮气呼吸肺功能的影响

Effects of Qingfei Pingchuan decoction on the tidal breathing lung function in children with respiratory syncytial virus pneumonia(phlegm-heat closing lung)

目的探讨清肺平喘汤对痰热闭肺型呼吸道合胞病毒肺炎婴幼儿潮气呼吸肺功能的影响。方法 2015年1月20日至2016年2月28日安康市中医医院儿科收治住院的呼吸道合胞病毒肺炎(痰热闭肺型)患儿140例,随机分为观察组和对照组各70例,因有部分患儿治疗过程根据纳入标准而剔除以及病例脱失,最后纳入病例观察组68例和对照组66例。对照组给予抗病毒,雾化吸入等对症治疗,合并细菌感染加用抗生素治疗。观察组在对照组基础上加用自制清肺平喘汤治疗,疗程7～14d。观察两组患儿症状体征消失时间、X线胸片吸收时间和住院时间;两组患儿治疗前后潮气呼吸肺功能变化情况。结果观察组总有效率为95.6%(65/68),显著高于对照组81.8%(54/66),差异有统计学意义(P<0.05)。观察组经治疗后退热、咳嗽、喘憋、肺部啰音消失时间,X线胸片吸收时间、住院时间均短于对照组,差异有统计学意义(P<0.05)。两组治疗前后潮气呼吸肺功能比较,吸气呼气时间比(T_I/T_E)、公斤潮气量(Vt/kg)、呼吸频率(RR)、达峰时间比(T_(PEF)/T_E)、达峰容积比(V_(PEF)/V_E)、剩余25%、50%、75%潮气量时的呼气流速(TEF 25%、TEF 50%、TEF 75%)检测差异有统计学意义(P<0.05);观察组与对照组治疗后比较公斤潮气量(Vt/kg)、达峰容积比(V_(PEF)/V_E)、达峰时间比(T_(PEF)/T_E)检测,差异有统计学意义(P<0.05)。结论痰热闭肺型呼吸道合胞病毒肺炎婴幼儿潮气呼吸肺功能明显受损,而且在临床症状缓解后,其肺功能明显改善,且观察组的公斤潮气量、达峰时间比和达峰容积比改善优于对照组。清肺平喘汤治疗呼吸道合胞病毒肺炎对改善患儿肺功能有显著作用。

Objective To investigate the effect of Qingfei Pingchuan decoction on tidal breathing lung function in infants with respiratory syncytial virus pneumonia(phlegm-heat closing lung).Methods A total of 140 children with respiratory syncytial virus pneumonia(phlegm-heat closing lung)were randomly divided into two groups,70 in the observation group and 70 in the control group.Because some children were eliminated during treatment due to the inclusion criteria and some were lost,finally the observation group consisted of 68 cases and the control group,66 cases.Both groups were given symptomatic treatment including antivirus treatment and inhalation,and antibiotics were used for those with bacterial infection.In addition,the observation group was treated with self-made Qingfei Pingchuan decoction for treatment.The treatment lasted for 7 to 14 days.The relief time of signs and symptoms,the absoption time of chest X-ray and the length of hospital stay were observed,and the changes in the tidal breathing lung function before and after treatment were also observed in the two groups.Results The total effective rate of observation group was 95.6%(65/68),significantly higher than that of control group(81.8%,54/66),there being statistical different(P<0.05).The time for fever,cough,asthma and lung rales to disappear,the absorption time of chest X-ray and the length of hospital stay were all shorter in the observation group than those in the control group after treatment,and there was statistical difference(P<0.05).Comparing the tidal breathing lung function of the two groups before and after treatment,there was statistical different in the detection of T I/T E,Vt/kg,RR,T PEF/T E,V PEF/V E,TEF 25%,TEF 50%and TEF 75%(P<0.05).Comparing the Vt/kg,V PEF/V E and T PEF/T E between the two groups after treatment,there was statistical difference(P<0.05).Conclusion The tidal breathing lung function is obviously damaged in children with respiratory syncytial virus pneumonia(phlegm-heat closing lung).After the clinical symptoms are relieved,the lung function is improved significantly,and the improvement in Vt/kg,T PEF/T E and V PEF/V E is greater in observation group than in control group.Qingfei Pingchuan decoction has significant effect in improving the lung function of children with respiratory syncytial virus pneumonia.