消斑汤联合西医治疗儿童过敏性紫癜疗效观察

Effect of Xiaoban decoction combined with western medicine on allergic purpura in children

目的探讨消斑汤联合西医治疗儿童过敏性紫癜的疗效。方法选取2014年5月至2017年5月漯河市第三人民医院儿科收治的过敏性紫癜患儿68例为研究对象,随机分为对照组和观察组各34例。对照组给予常规西医治疗,观察组在对照组基础上给予消斑汤治疗,观察两组临床疗效、凝血功能指标和临床主要症状体征改善情况。结果观察组临床总有效率为97.06%(33/34),显著高于对照组73.53%(25/34),差异有统计学意义(P<0.05)。观察组皮疹、腹痛、关节肿痛及血尿消失时间显著短于对照组,差异有统计学意义(P<0.05)。观察组治疗后凝血功能指标凝血酶原时间、凝血活酶时间水平显著高于对照组,纤维蛋白原水平显著低于对照组,差异有统计学意义(P<0.05)。两组均未发生明显不良反应。结论消斑汤联合西医治疗儿童过敏性紫癜疗效及止血效果显著,可快速改善患儿相关症状,临床应用安全性高。

Objective To explore the effect of Xiaoban decoction combined with western medicine on allergic purpura in children.Methods A total of 68 children with allergic purpura were randomly divided into control group(34 cases)and observation group(34 cases).Both groups were given conventional western medicine;besides,the observation group was given additional Xiaoban decoction.The curative effects coagulation indexes and improvement in the main symptoms and signs of the two groups were observed and compared.Results The total effective rate in the observation group was 97.06%(33/34),which was significantly higher than that in the control group(73.53%,25/34,P<0.05).The disappearance time of rash,abdominal pain,joint swelling and pain,and hematuria in the observation group was significantly shorter than that in the control group(P<0.05).After treatment,the PT and APTT levels in the observation group were significantly higher than those in the control group,while the level of FIB was lower(P<0.05).There was no obvious adverse reactions in the two groups.Conclusion Xiaoban decoction combined with western medicine has significant curative and hemostatic effects for children with allergic purpura,which can quickly improve the related symptoms of children and is with high safety.