不同治疗方法对肾阳虚型男性不育症患者睾酮和精子的影响

Effects of different treatments on testosterone and sperm in patients with kidney-yang deficiency male infertility

目的观察不同治疗方法对肾阳虚型男性不育症患者睾酮和精子的影响。方法选取2015年9月至2018年6月在我院中医门诊接受治疗的辨证为肾阳虚型的男性不育症患者203例为研究对象,采用随机数字表法分为研究组(100例)和对照组(103例)。研究组患者采用温阳赞育汤治疗,对照组患者采用五子衍宗丸治疗,治疗1个月为1个疗程,连续治疗3个疗程。比较两组患者治疗前后的血清睾酮水平、精子形态、精液量以及精子液化时间。结果治疗3个月后,研究组患者的治疗总有效率为83. 0%,对照组为66. 0%,两组比较差异有统计学意义(P <0. 05);治疗后两组患者的血清睾酮水平均显著升高,正常形态精子及精液量显著增多、精子液化时间显著缩短;研究组患者血清睾酮水平、正常形态精子百分率、精液量显著高于对照组,精子液化时间显著短于对照组,差异有统计学意义(P <0. 05)。结论与采用五子衍宗丸治疗比较,温阳赞育汤治疗肾阳虚型不育症患者能更有效地改善其血清睾酮水平及精液质量。

Objective To observe the effects of different treatments on testosterone and sperm in patients with kidney-yang deficiency male infertility.Methods 203 cases of male infertility patients with kidney yang deficiency were treated in our hospital from September 2015 to June 2018,which were randomly divided into study group(100 cases)and control group(103 cases).The study group were treated with Wenyang Zanyu decoction,and the control group were treated with Wuzi Yanzong pill.The treatment was 1 month for 1 course and 3 courses for continuous treatment.Serum testosterone levels,sperm morphology,semen volume,and liquefaction time were compared between the two groups before and after treatment.Results After 3 months′treatment,the total effective rate of the study group was 83.0%,and the control group was 66.0%;the difference between the two groups was statistically significant(P<0.05).After treatment,the serum testosterone levels of the two groups were significantly increased.The normal morphology of sperm and semen increased significantly,and the sperm liquefaction time was significantly shortened.The serum testosterone level,normal spermatozoa rate and semen volume in the study group were significantly higher than those in the control group.The sperm liquefaction time was significantly shorter than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Wenyang Zanyu Decoction can improve the serum testosterone level and semen quality more effectively than Wuzi Yanzong pill in patients with kidney yang deficiency infertility.