国医大师刘尚义治疗肝癌用药规律研究

Study on Medication Rules of TCM Master LIU Shang-yi for Treatment of Hepatocarcinoma

目的分析刘尚义教授治疗肝癌用药特点,为临床治疗提供参考。方法收集刘尚义教授2014年3月-2016年8月在贵州省中医医院国医堂门诊治疗的肝癌病案,采用中医传承辅助平台(V2.5)对纳入处方进行药物性味、频次、配伍规律、核心药物组合等分析。结果纳入处方318首,涉及药味137味,总频次2931次。高频药物有莪术、醋鳖甲、冬凌草、猫爪草、田基黄等;方中寒温并用,辛、苦、甘味药物居多。挖掘得到高频药物组合分别为2味药68组、3味药100组,4味药72组,包括"莪术-醋鳖甲""莪术-冬凌草""醋鳖甲-冬凌草"等。结论刘尚义教授治疗肝癌处方用药多具养阴软坚、清热解毒功效,体现了其扶正祛邪、调整阴阳的治疗思路。

Objective To explore the medication features of Professor LIU Shang-yi for the treatment of hepatocarcinoma;To provide references for the clinic.Methods Medical cases about hepatocarcinoma treated by Professor LIU Shang-yi in National Medical Center Clinic of Guizhou Provincial TCM Hospital from March 2014 to August 2016 were collected.TCM inheritance support platform software V2.5 was used to analyze properties and flavors,frequency,compatibility law and core medicine combinations.Results Totally 318 prescriptions were included in the study,involving 137 kinds of Chinese materia medica and frequency of 2931 times.The medicines with high frequency were Curcumae Rhizoma,vinegar Trionycis Carapax,Rabdosiae Rubescentis Herba,Ranunculi Ternati Radix and Hypericum Japonicum Thunb;cold and warm were used in the prescriptions,and there were a lot of medicines with flavors of spicy,bitter and sweet.68 groups of two medicines,100 groups of three medicines and 72 groups of four medicines with high frequency were obtained by data mining.High frequency association rules were“Curcumae Rhizoma-vinegar Trionycis Carapax”,“Curcumae Rhizoma-Rabdosiae Rubescentis Herba”,“vinegar Trionycis Carapax-Rabdosiae Rubescentis Herba”.Conclusion The prescriptions for the treatment of hepatocarcinoma by Professor LIU Shang-yi have the efficacy of tonifying yin,and resolving masses,clearing heat and detoxifying,which shows the treatment principles of strengthening body resistance and eliminating evil,and adjusting yin and yang.