肠道菌群与结直肠癌发病风险的Meta分析

Meta analysis of intestinal flora and risk of colorectal cancer

从循证医学角度评价肠道菌群差异与结直肠癌发病风险的关联.以肠癌、结直肠癌、肠道菌群和肠道微生态作为检索词,分别对知网、万方和维普数据库检索关于肠道菌群与结直肠癌关系的文献,使用Review Manager 5.3进行Meta分析.双歧杆菌和乳酸杆菌合并的均数差均小于0,大肠埃希菌、屎肠球菌和粪肠球菌合并的均数差均大于0,结直肠癌患者粪便中有益菌减少,有害菌增加.这说明结直肠癌患者体内肠道菌群出现微生态失调,这可能与结直肠癌的产生与发展有关,人们在日常生活中应当重视肠道菌群的微生态调理.

Evaluates the relationship between intestinal flora and risk of colorectal cancer from the perspective of evidence-based medicine.Intestinal cancer,colorectal cancer,intestinal flora and intestinal micro-ecology were used as search terms to search the literature on the relationship between intestinal flora and colorectal cancer in the HowNet,Wanfang and Weipu databases,and use Review Manager 5.3 for Meta analysis.The mean difference between Bifidobacterium and Lactobacillus was less than 0,and the mean difference between Escherichia coli,Enterococcus faecium and Enterococcus faecalis was greater than 0.The number of beneficial bacteria in the stool of patients with colorectal cancer is reduced,and harmful bacteria are increased.This indicates that micro-ecological disorders occur in the intestinal flora of patients with colorectal cancer,and micro-ecological disorders in the intestinal flora may be related to the development of colorectal cancer.People should pay attention to the micro-ecological conditioning of intestinal flora in daily life.