腹腔镜袖状胃切除术在治疗睡眠呼吸暂停综合征中的应用价值

The Application value of Laparoscopic Sleeve Gastrectomy on Obesity and Obstructive Sleep Apnea-Hypopnea Syndrome

目的探讨腹腔镜袖状胃切除术(LSG)在治疗睡眠呼吸暂停综合征中的应用价值。方法回顾性分析2015年9月至2017年4月在中南大学湘雅三医院接受LSG治疗的20例肥胖合并睡眠呼吸暂停综合征患者的临床资料。其中男性17例,女性3例,平均年龄为(39.0±10.2)岁,平均体质量指数(BMI)为(42.71±9.32) kg/m^2;记录术前和术后3个月的患者体重、身高、BMI以及多导睡眠监测中紊乱指数(AHI)、最低血氧饱和度(LSaO_2)等指标。采用配对t检验比较手术前后的临床指标、采用Pearson相关分析数据间的相关性。结果术后3个月,患者体重由术前的(119.96±28.33)kg,降到了术后的(96.77±22.71)kg;BMI由术前的(42.71±9.32)kg/m^2,降到了术后的(34.17±7.30)kg/m^2;AHI由术前的(46.80±20.75),降到了术后的(26.89±15.31);LSaO_2由术前的(63.15±11.74),提升到了术后的(76.17±10.21),所有患者的体重及睡眠呼吸相关指标均明显改善。结论 LSG对治疗肥胖合并睡眠呼吸暂停综合征的短期疗效确切。

Objective To explore the application value of laparoscopic sleeve gastrectomy(LSG)on obesity and obstructive sleep apnea-hypopnea syndrome(OSAHS).Methods This study retrospectively analyzed 20 patients of obese with obstructive sleep apnea-hypopnea syndrome who underwent LSG in The Third Xiangya Hospital of Central South University from September 2015 to April 2017.Data were collected before surgery and 3 months after surgery,including body weight,height and calculated body mass index(BMI),apnea-hypopnea index(AHI)and the lowest SaO2(LSaO2)were obtained from polysomnography(PSG).Statistical analysis was carried out using SPSS for Windows version 22.0.All continuous variable values were expressed as mean±SD.Paired-Samples T Test and Pearson correlative analysis were used.The signifi cance level of this study was set at a two-tailedα=0.05.Results At 3 months after the surgery,all patients'body weight decreased from(119.96±28.33)kg to(96.77±22.71)kg,BMI decreased from(42.71±9.32)kg/m2 to(34.17±7.30)kg/m2,AHI decreased from(46.80±20.75)to(26.89±15.31)and LSaO2 increased from(63.15±11.74)to(76.17±10.21).Conclusion This article showed that LSG is an eff ective treatment for the management of OSAHS in morbidly obese patients.