派特灵治疗子宫颈锥切术及子宫切除术后高危型人乳头瘤病毒感染的疗效评价

The clinical observation of paiteling on treatment of HPV infection after conization and hysterectomy

目的宫颈上皮内瘤变或宫颈癌行子宫颈锥切术或子宫切除术后复查仍存高危型人乳头瘤病毒感染,预防术后发生子宫颈病变或阴道断端病变是有效治疗高危型人乳头瘤病毒感染重要方法。应用派特灵与辛复宁对比治疗高危型人乳头瘤病毒感染的疗效。方法将患者随机分成观察组(派特灵)30例,对照组(辛复宁)28例,派特灵每天1次,连用3天后停用4天,共6个疗程。对照组于睡前清洁外阴后将1粒辛复宁置于后穹窿或阴道断端,每天1次,10天为一个疗程,共6个疗程。结果观察组高危型人乳头瘤病毒检测转阴者23例,转阴率为76.7%(23/30),对照组转阴者13例,转阴率为46.4%(13/28),观察组高危型人乳头瘤病毒检测转阴率显著高于对照组,差异有统计学意义(P<0.05)。结论派特灵治疗子宫颈锥切术及子宫切除术后高危型人乳头瘤病毒感染具有显著优势,值得临床推广应用。

Objective To compare the therapeutic effect of paiteling and Xingfuning in the treatment of high-risk HPV infection after conization and hysterectomy.Methods 58 cases of women were randomized into paiteling group(n=30)and Xinfuning group(n=28),paiteling was given for 6 courses,once a day for 3 days and then stop using for 4 days,Xingfuning was placed in posterior fornix of vagina or vaginal cuff before sleep after vulvae cleaning for 6 courses,a pill once a day for 10 days.Results The HPV negative rate was 76.7%(23/30)in paiteling group,higher than 46.4%(13/28)in Xinfuning group,the difference was statistically significant(P<0.05).Conclusion Paiteling treatment for HPV infection after conization and hysterectomy with is more obvious,worth clinical promotion.