摘要
为了解自制的姜酮复合微粉对肥胖型2型糖尿病小鼠的减肥及降血糖作用,采用db/db小鼠为肥胖型2型糖尿病模型小鼠,给予姜酮复合微粉Ⅰ和姜酮复合微粉Ⅱ,通过葡萄糖耐量试验、胰岛素耐量试验以及组织切片技术等,观察姜酮复合微粉的作用。结果显示姜酮复合微粉Ⅰ和姜酮复合微粉Ⅱ在给药7 d后小鼠血糖值分别降至(6.20±1. 27) mmol/L和(3.83±1. 88) mmol/L,且用药28 d期间血糖维持稳定;服用姜酮复合微粉Ⅰ和姜酮复合微粉Ⅱ小鼠的葡萄糖水平曲线下的面积(AUC)与模型对照组相比显著降低;服用姜酮复合微粉Ⅱ小鼠腹部脂肪质量显著降低,服用姜酮复合微粉Ⅰ和姜酮复合微粉Ⅱ小鼠脂肪细胞明显缩小。说明该姜酮复合微粉具有显著降低肥胖型2型糖尿病小鼠血糖和减肥的作用。
In order to investigate the effect of zingerone compound powder(ZCP)on hyperglycemia and obesity in obesity type 2 diabetic mice,Db/db mice were used as model mice for obesity type 2 diabetes mellitus,and the ZCPⅠand ZCPⅡwere given.Glucose tolerance test,insulin tolerance test and tissue slice technique were used to observe the effect of ZCP.The results showed that the blood glucose of the mice taking ZCPⅠand ZCPⅡdecreased to(6.20±1.27)mmol/L and(3.83±1.88)mmol/L after seven days of administration,and blood glucose remained stable for four weeks.The area under the glucose level curve(AUC)of the mice taking ZCPⅠand ZCPⅡsignificantly decreased compared with that of the model control group.The weight of abdominal fat of the mice taking ZCPⅡwas significantly decreased.The size of adipocytes of the mice taking ZCPⅠand ZCPⅡdecreased significantly.The results showed that the ZCP had a significant effect on reducing blood glucose and weight loss in obesity type 2 diabetic mice.
作者
陈俊红
孙敬
陆雨楠
马平平
沈伟奇
朱秋阳
戴鼎震
CHEN Jun-hong;SUN Jing;LU Yu-nan;MA Ping-ping;SHEN Wei-qi;ZHU Qiu-yang;DAI Ding-zhen(Institute of Comparative Medicine,Yangzhou University,Yangzhou 225009,China;College of Veterinary Medicine,Yangzhou University,Yangzhou 225009,China;Institute of Animal Science and Technology,Jinling Institute of Technology,Nanjing 211169,China)
出处
《江苏农业学报》
CSCD
北大核心
2018年第5期1095-1099,共5页
Jiangsu Journal of Agricultural Sciences
基金
江苏省自然科学基金青年基金项目(BK20150450)
金陵科技学院"创客虚拟班"立项项目(2017CK008
2017CK009)
关键词
姜酮复合微粉
2型糖尿病
高血糖
肥胖
zingerone compound powder
type 2 diabetes
high blood glucose
obesity